Anna Santoro | Biochemistry, Genetics and Molecular Biology | Research Excellence Award

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Dr. Anna Santoro | Biochemistry, Genetics and Molecular Biology | Research Excellence Award

Beth Israel Deaconess Medical Center | United States

Dr. Anna Santoro’s research profile reflects a strong and sustained contribution to biomedical and toxicological sciences, with a particular focus on inflammatory pathways, metabolic regulation, environmental toxicants, and neuroendocrine mechanisms. Her scholarly output comprises 28 peer-reviewed documents, which together have received 1,584 citations across 1,472 citing documents, demonstrating broad international impact and cross-disciplinary relevance. With an h-index of 22, her work shows both productivity and consistent citation performance. Key investigations explore the biological effects of non-dioxin-like polychlorinated biphenyls on cellular apoptosis, lipid metabolism, and endocrine signaling, alongside influential studies on palmitoylethanolamide and its protective roles in metabolic disorders, hypertension, renal injury, and neuroinflammation. Her publications in high-impact journals such as Toxicology Letters, Endocrinology, PLoS One, and Journal of Nutritional Biochemistry highlight rigorous experimental approaches and translational relevance, positioning her research as a significant reference point in toxicology, pharmacology, and metabolic disease research.

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Featured Publications

Judith Röske | Biochemistry, Genetics and Molecular Biology | Women Research Award

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Mrs. Judith Röske | Biochemistry, Genetics and Molecular Biology | Women Research Award

University of Luebeck | Germany

Mrs. Judith Röske is a dedicated researcher with a strong focus on molecular virology, antiviral drug discovery, and protease-targeted therapeutic development, contributing to 13 scientific publications across high-impact journals. Her work explores the binding behavior of small-molecule inhibitors to viral 3C proteases, including SARS-CoV-2, EV-D68, EV-A71, and HAV, as well as host proteases such as cathepsins and calpain-1. With expertise in photometry, nanoDSF, MST, and SPR, she has optimized methods for determining key biochemical parameters such as IC₅₀, Tm, and Kᴅ, enabling the effective screening of lead compounds for broad-spectrum antivirals. Her research further investigates RNA-binding mechanisms in HAV 3C protease, shedding light on dual-targeting strategies that may advance anti-picornaviral drug development. She has contributed to influential studies on SARS-CoV-2 main protease inhibitors, including work on novel warhead chemistries, α-ketoamide derivatives, and diastereomeric optimization, reinforcing her impact in antiviral medicinal chemistry. Additionally, earlier contributions in transplant biology and liver preservation highlight her versatility in biochemical and molecular research. Through rigorous structural, kinetic, and biophysical analyses, her body of work adds valuable insight into protease inhibition and therapeutic innovation, supported by a growing citation record within the scientific community.

Profiles : Scopus | Orcid

Featured Publications

Theodoropoulou, M. A., El Kilani, H., Mantzourani, C., Jochmans, D., Neyts, J., Zhang, K., Röske, J., Kokotou, M. G., Hilgenfeld, R., & Kokotos, G. (2025). Thiazolyl 4-carboxylate ketone as a new warhead for a highly potent SARS-CoV-2 main protease inhibitor. European Journal of Medicinal Chemistry, 25(11), 118436.

Akula, R. K., El Kilani, H., Metzen, A., Röske, J., Zhang, K., Göhl, M., Arisetti, N., Marsh, G. P., Maple, H. J., Cooper, M. S., et al. (2025). Structure-based optimization of pyridone α-ketoamides as inhibitors of the SARS-CoV-2 main protease. Journal of Medicinal Chemistry, 68(1).

Cooper, M. S., Zhang, L., Ibrahim, M., Zhang, K., Sun, X., Röske, J., Göhl, M., Brönstrup, M., Cowell, J. K., Sauerhering, L., et al. (2022). Diastereomeric resolution yields highly potent inhibitor of SARS-CoV-2 main protease. Journal of Medicinal Chemistry.

Bernard, V., Gebauer, N., Dinh, T., Stegemann, J., Feller, A. C., & Merz, H. (2014). Applicability of next-generation sequencing to decalcified formalin-fixed and paraffin-embedded chronic myelomonocytic leukaemia samples. International Journal of Clinical and Experimental Pathology.

Le Minh, K., Berger, A., Eipel, C., Kuhla, A., Minor, T., Stegemann, J., & Vollmar, B. (2011). Uncoupling protein-2 deficient mice are not protected against warm ischemia/reperfusion injury of the liver. Journal of Surgical Research, 167.

Stegemann, J., Hirner, A., Rauen, U., & Minor, T. (2010). Use of a new modified HTK solution for machine preservation of marginal liver grafts. Journal of Surgical Research.

Koetting, M., Stegemann, J., & Minor, T. (2010). Dopamine as additive to cold preservation solution improves postischemic integrity of the liver. Transplant International, 23.

Minor, T., Stegemann, J., Hirner, A., & Koetting, M. (2009). Impaired autophagic clearance after cold preservation of fatty livers correlates with tissue necrosis upon reperfusion and is reversed by hypothermic reconditioning. Liver Transplantation.

Stegemann, J., & Minor, T. (2009). Energy charge restoration, mitochondrial protection and reversal of preservation-induced liver injury by hypothermic oxygenation prior to reperfusion. Cryobiology.

Stegemann, J., Hirner, A., Rauen, U., & Minor, T. (2009). Gaseous oxygen persufflation or oxygenated machine perfusion with Custodiol-N for long-term preservation of ischemic rat livers? Cryobiology.

Le Minh, K., Kuhla, A., Abshagen, K., Minor, T., Stegemann, J., Ibrahim, S., Eipel, C., & Vollmar, B. (2009). Uncoupling protein-2 deficiency provides protection in a murine model of endotoxemic acute liver failure. Critical Care Medicine.

Manekeller, S., Seinsche, A., Stegemann, J., & Hirner, A. (2008). Optimising post-conditioning time of marginal donor livers. Langenbeck's Archives of Surgery.

Manekeller, S., Schuppius, A., Stegemann, J., Hirner, A., & Minor, T. (2007). Role of perfusion medium, oxygen and rheology for endoplasmic reticulum stress-induced cell death after hypothermic machine preservation of the liver. Transplant International.

Giovanni Smaldone | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Dr. Giovanni Smaldone | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

IRCCS Synlab SDN | Italy

Dr. Giovanni Smaldone is a highly accomplished researcher whose work spans molecular biology, structural biochemistry, oncology, immunology, and advanced diagnostic technologies. With 1,037 citations, 83 published works, and an h-index of 18, his contributions reflect both productivity and strong scientific impact. His research integrates structural biology, NMR spectroscopy, molecular interactions, and translational oncology, with a particular emphasis on childhood acute lymphoblastic leukemia (ALL). He has led and contributed to numerous funded research projects, including competitive grants focused on long non-coding RNAs, epigenetic markers, and the KCTD protein family in pediatric leukemia. His studies also extend into protein delivery systems, nanogels, cellular imaging, and biobank development for rare pediatric disorders. Dr. Smaldone’s recent publications highlight advancements in 3D refractive index tomography for leukemia cell analysis, targeted drug-delivery platforms, diagnostic biomarkers such as circular RNAs and LINC00958, and the structural mechanisms underlying KCTD–Cullin 3 interactions. His work frequently appears in high-impact journals across molecular sciences, biomedical engineering, nanotechnology, and clinical research. Additionally, he has presented widely at national and international scientific conferences, contributing to knowledge dissemination in cellular biophysics, protein structure, pediatric oncology, and advanced molecular diagnostics.

Profiles : Scopus | Orcid

Featured Publications

Bianco, V., Pirone, D., Schiavo, M., Bianco, V., Miccio, L., Memmolo, P., Smaldone, G., Pecoraro, G., Altieri, F., Salvatore, M., et al. (2026). Quantitative mapping of leukemia cells and intracellular lipid droplets using 3D refractive index tomography in flow cytometry. IEEE Journal of Selected Topics in Quantum Electronics.

Pizzella, M., Accardo, A., Mercurio, F. A., Sibillano, T., Gallo, E., Morelli, G., Smaldone, G., Giannini, C., Leone, M., Balasco, N., et al. (2025). Structural and functional characterization of self-assembling fragments identified from the transthyretin amyloid-like structure. Nanoscale.

Leone, I., Costabile, V., Smaldone, G., Franzese, M., Soricelli, A., & D’Agostino, A. (2025). Arthrospira platensis attenuates endothelial inflammation and monocyte activation. International Journal of Molecular Sciences.

Gallo, E., Smaldone, G., Cimmino, L., Braile, M., Orlandella, F. M., Luciano, N., Accardo, A., & Salvatore, G. (2025). Fmoc-FF nanogel-mediated delivery of doxorubicin and curcumin in thyroid cancer cells. Pharmaceutics.

Balasco, N., Esposito, L., Smaldone, G., Salvatore, M., & Vitagliano, L. (2024). A comprehensive analysis of the structural recognition between KCTD proteins and Cullin 3. International Journal of Molecular Sciences.

Bianco, V., Wang, Z., Brancato, V., Coppola, L., Smaldone, G., D’Aiuto, M., Mossetti, G., Maffettone, P. L., Salvatore, M., & Ferraro, P. (2024). Adaptive space-time digital holography for imaging flow cytometry and tissue slide analysis. In Digital Holography and Three-Dimensional Imaging (DH 2024).

Coppola, L., Grimaldi, A. M., Sarnacchiaro, G., Di Fasano, M. S., Smaldone, G., & Salvatore, M. (2024). An overview of Synlab SDN Biobank’s quality control system. Scientific Reports.

De Martino, L., Mirabelli, P., Quaglietta, L., Ferrara, U. P., Picariello, S., De Gennaro, D. V., Aiello, M., Smaldone, G., Aliberti, F., Spennato, P., et al. (2024). Biobank for craniosynostosis and faciocraniosynostosis: A study protocol. Child’s Nervous System.

Bianco, V., Valentino, M., Pirone, D., Miccio, L., Memmolo, P., Brancato, V., Coppola, L., Smaldone, G., D’Aiuto, M., & Mossetti, G. (2024). Classifying breast cancer and fibroadenoma tissue biopsies using fractal biomarkers in Fourier ptychographic microscopy. Computational and Structural Biotechnology Journal.

De Martino, L., Mirabelli, P., Quaglietta, L., Ferrara, U. P., Picariello, S., De Gennaro, D. V., Aiello, M., Smaldone, G., Aliberti, F., Spennato, P., et al. (2024). Correction: Biobank for craniosynostosis and faciocraniosynostosis. Child’s Nervous System.

Gallo, E., Diaferia, C., Smaldone, G., Rosa, E., Pecoraro, G., Morelli, G., & Accardo, A. (2024). Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells. Scientific Reports.

Gallo, E., Diaferia, C., Smaldone, G., Rosa, E., Pecoraro, G., Morelli, G., & Accardo, A. (2024). Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells. Research Square.

Filomena, A., Smaldone, G., Ginevra, S., Santiago, N., Di Fasano, M. S., Peppino, M., Alessandra, C., Antonia, D. M., Giuliana, B., Rosanna, P., et al. (2024). Identification of a circular RNA isoform of WASHC2A as a prognostic factor for high-risk pediatric B-ALL. Biomedicine & Pharmacotherapy.

Raymundo, J. R., Zhang, H., Smaldone, G., Zhu, W., Daly, K. E., Glennon, B. J., Pecoraro, G., Salvatore, M., Devine, W. A., Lo, C. W., et al. (2024). KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions. Journal of Clinical Investigation.

Altieri, F., Buono, L., Lanzilli, M., Mirabelli, P., Cianflone, A., Beneduce, G., De Matteo, A., Parasole, R., Salvatore, M., & Smaldone, G. (2024). LINC00958 as a diagnostic and prognostic biomarker of childhood B-cell acute lymphoblastic leukemia. Frontiers in Oncology.

Sophie Grigolo | Immunology and Microbiology | Young Researcher Award

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Mrs. Sophie Grigolo | Immunology and Microbiology | Young Researcher Award

University of Fribourg | Switzerland

Mrs. Sophie Grigolo is an emerging researcher specializing in cellular and molecular biology, with a strong focus on cancer research, particularly clear-cell renal-cell carcinoma (ccRCC). Her work encompasses extensive laboratory expertise in cell culture using human kidney cancer cell lines (A-498, ACHN, Caki-1, and Caki-2) and a range of analytical assays including BrdU Cell Proliferation, MTT, LDH, and Live-or-Dye™ Fixable Viability Staining. She is proficient in advanced molecular biology techniques such as polymerase chain reaction (PCR), agarose gel electrophoresis, western blotting, genotyping, flow cytometry, and immunohistochemistry (IHC), which she applies to elucidate cancer cell behavior and therapeutic responses. Her publications, including studies on immunotherapy in ccRCC and the role of IL-2 receptor expression in renal carcinoma cells, contribute to advancing understanding of tumor immunology and targeted therapies. Sophie has also shared her findings at prestigious scientific forums, including the International Student Congress of (bio)Medical Sciences and the Annual European Student Symposium on Anatomical Research, where her work has earned recognition for excellence. Through her research and technical acumen, she continues to contribute to the evolving field of cancer biology and the development of innovative therapeutic approaches.

Profile : Orcid

Featured Publications

Grigolo, S., Fellay, I., & Filgueira, L. (2025). IL-2 receptor expression in renal cell carcinoma cells: IL-2 influences cell survival and induces cell death. Current Issues in Molecular Biology, 47(10), 830.

Grigolo, S., & Filgueira, L. (2024). Immunotherapy of clear-cell renal-cell carcinoma. Cancers, 16, 2092.

Anita Kavrakova | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Mrs. Anita Kavrakova | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

Genetic Medico-Diagnostic Laboratory “Genica” | Bulgaria

Mrs. Anita Kavrakova is a distinguished molecular biologist and project manager with extensive experience in medical genetics and diagnostic research. Since 2019, she has been serving as Project Manager at Genetic Medico-Diagnostic Laboratory “Genica” and Genome Center Bulgaria AD in Sofia, where she oversees laboratory projects, implements innovative diagnostic techniques, ensures compliance with national and international standards, and actively contributes to scientific research through conferences, publications, and collaborative studies. Prior to this role, she worked as a Molecular Biologist at Genica (2008–2018), conducting advanced molecular analyses including PCR, qPCR, gene sequencing, and immunohistochemistry, with a focus on cancer genetics, particularly prostate and cervical cancers. She has also been a part-time assistant at the Department of Medical Chemistry and Biochemistry, Medical University Sofia, since 2012, training students in theoretical and practical biochemistry. Dr. Kavrakova earned her PhD in Genetics from Medical University Sofia in 2015, investigating molecular markers in prostate cancer for improved diagnostics and patient management, following an MS in Genetics and a Bachelor in Biology from Sofia University “St Kliment Ohridski.” She has contributed to numerous national and international research projects on infectious agents, reproductive failure, and cancer etiology, authored multiple publications, and actively participates in innovation evaluation and scientific advisory roles, demonstrating leadership, analytical skills, and a commitment to advancing molecular diagnostics and biomedical research.

Profiles : Scopus | Orcid

Featured Publications

Todorova, E., Kavrakova, A., Derimachkovski, G., Georgieva, B., Odzhakov, F., Bachurska, S., Terziev, I., Boyadzhieva, M. E., Valkov, T., Popov, E., Slavov, C., Tourtourikov, I., Mitev, V., & Todorova, A. (2025). Human Herpes Virus genotype and immunological gene expression profile in prostate cancer with prominent inflammation. International Journal of Molecular Sciences, 26(10), 4945.

Todorova, E., & Kavrakova, A., Derimachkovski, G., Georgieva, B., Kalenderova, S., Odzhakov, F., Bachurska, S., Boyadzhieva, M. E., Terziev, I., Genova, M., Mitev, V., & Todorova, A. (2025). Pathogenic contribution of human papillomaviruses and Epstein-Barr virus to prostate cancer in Bulgarian patients. C. R. Acad. Bulg. Sci. (submitted).

Mesechkova, K., Kavrakova, A., Georgieva, B., Sigridov, I., Miteva, A., Mitev, V., & Todorova, A. (2023). Bacterial and viral pathogens implicated in female reproductive failure investigated on menstrual blood. C. R. Acad. Bulg. Sci., 76(3), 394–406.

Mesechkova, K., Kavrakova, A., Georgieva, B., Sigridov, I., Mitev, V., & Todorova, A. (2023). Non-invasive diagnostics of reproductive failure with infectious etiology on menstrual tissue. Acta Medica Bulgarica, 50(3).

Mesechkova, K., Kavrakova, A., Todorova, E., Georgieva, B., Sigridov, I., Mitev, V., & Todorova, A. (2023). Role of bacterial and viral infections and co-infections in miscarriages. Acta Medica Bulgarica, 50(4).

Kavrakova, A., Todorova, A., Georgieva, B., Anachkov, K., Yanev, K., Ivanov, G., & Mitev, V. (2018). Investigation of noninvasive urine specimens with molecular fluctuations for a presence of high-risk human papilloma viruses as an inflammatory cofactor in prostate cancer. Journal of Biology and Medicine.

Tsvetkova, A., Todorova, A., Todorov, T., Georgiev, G., Drandarska, I., & Mitev, V. (2015). Molecular and clinico-histological data in aggressive prostate cancer patients from Bulgaria. JBUON, 20(2).

Tsvetkova, A., Todorova, A., Todorov, T., Georgiev, G., Drandarska, I., & Mitev, V. (2015). Molecular and clinicopathological aspects of prostate cancer in Bulgarian probands. Journal of Pathology and Oncology Research.

Tsvetkova, A., Todorova, A., Todorov, T., Georgiev, G., Drandarska, I., & Mitev, V. (2014). Molecular profile and clinicopathological aspects of prostate cancer in Bulgarian patients. Journal of BOD, 4, 18–26.

Tsvetkova, A., Kadiyska, T., Georgiev, G., Drandarska, I., Todorova, A., & Mitev, V. (2013). Molecular-genetic approach in combination with clinical and histological data for diagnostics of prostate cancer. Journal of Oncology, 3, 50–55.

 

 

Valentina Mihaylova | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Mrs. Valentina Mihaylova | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

Medical University-Plovdiv | Bulgaria

Mrs. Valentina Mihaylova is a dedicated researcher and specialist in medical chemistry with a strong focus on cellular metabolism, mitochondrial function, oxidative stress, and autoimmune diseases. With an h-index of 2, she has authored five scientific publications, which have collectively garnered 14 citations, reflecting her growing impact in medical biology and clinical research. Her work encompasses the study of markers of oxidative stress and insulin resistance in chronic autoimmune Hashimoto’s thyroiditis, cellular metabolic profiling in children with autism spectrum disorders, and the evaluation of therapeutic effects in rheumatoid arthritis through mitochondrial function and bioenergetic metabolism. Mrs. Mihaylova’s research also explores intestinal permeability, systemic inflammation, and the pharmacological effects of treatments such as methotrexate and JAK inhibitors on mitochondrial function and oxidative stress. She has actively contributed to numerous national and international conferences, presenting pioneering findings on the role of mitochondria, autophagy, and inflammation in autoimmune and rheumatologic conditions. Her academic and professional trajectory, spanning positions from clinical chemist to Master of Medical Chemistry at the Medical University of Plovdiv, is marked by a commitment to advancing knowledge in medical biology and translational research. Through her multidisciplinary approach, Mrs. Mihaylova continues to elucidate complex biochemical mechanisms underlying disease pathology and therapeutic responses, establishing herself as an emerging contributor to the field of medical and clinical biochemistry.

Profiles : Scopus | Orcid

Featured Publications

Mihaylova, V., Tomov, D., Karalilova, R., Batalov, Z., Batalov, A., Sarafian, V., & Kazakova, M. (2025). Effects of methotrexate and tofacitinib on mitochondrial function and oxidative stress in human synovial cells in vitro. International Journal of Molecular Sciences, 26(17), 8173.

Tomov, D. G., Levterova, B. A., Mihaylova, V. N., Troev, D. M., Miteva, M. Z., Uzunova, Y. I., & Orbetzova, M. M. (2024). Influence of the increase in intestinal permeability and microbiota change in the development of Hashimoto's thyroiditis: A systematic review. Endocrine and Metabolic Science, 100195.

Mihaylova, V., Kazakova, M., Batalov, Z., Karalilova, R., Batalov, A., & Sarafian, V. (2023). JAK inhibitors improve ATP production and mitochondrial function in rheumatoid arthritis: A pilot study. Rheumatology International.

Kazuto Ikemoto | Agricultural and Biological Sciences | Best Researcher Award

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Dr. Kazuto Ikemoto | Agricultural and Biological Sciences | Best Researcher Award

Mitsubishi Gas Chemical Company | Japan

Dr. Kazuto Ikemoto is a distinguished researcher and Senior Scientist at the Niigata Research Laboratory of Mitsubishi Gas Chemical Company, Inc., Japan. With a Ph.D. in Chemistry from Nagasaki University, he has made significant contributions to the fields of chemistry, food functionality, biotechnology, and semiconductor cleaning technologies. His extensive research portfolio includes 25 published documents, reflecting a deep engagement in both industrial and scientific innovation. Dr. Ikemoto’s scholarly influence is evidenced by 453 citations from 291 documents and an h-index of 13, underscoring the consistent impact of his research within the scientific community. His work bridges fundamental chemistry with practical industrial applications, advancing methodologies in material science and biochemical processes. Recognized for his outstanding achievements in corporate research, Dr. Ikemoto received the prestigious JSBBA Award for Corporate Researchers in 2023, highlighting his dedication to innovation and excellence. Through his pioneering studies and leadership at Mitsubishi Gas Chemical Company, he continues to drive advancements that contribute to technological development and sustainability, reinforcing his reputation as a leading figure in applied chemical research and industrial biotechnology.

Profiles : Scopus | Orcid

Featured Publications

Koshizawa, T., Numaguchi, T., Tamakoshi, M., Sato, Y., Hashimoto, K., Mohamad Ishak, N. S., & Ikemoto, K. (2025). High-spermidine-producing yeast strain for autophagy-promoting applications. Processes.

Koshizawa, T., Numaguchi, T., Tamakoshi, M., Sato, Y., Hashimoto, K., Mohamad Ishak, N. S., & Ikemoto, K. (2025). High-spermidine-producing yeast strain for autophagy-promoting applications [Preprint].

Mohamad Ishak, N. S., & Ikemoto, K. (2025). Direct HPLC method for reduced pyrroloquinoline quinone in functional and biological matrices [Preprint].

Sugimoto, J., Ikemoto, K., Nagamatsu, K., Mino, A., & Nakamura, F. (2025). ピロロキノリンキノンジナトリウム（PQQ）摂取後の20から65歳の健康な大人に対する認知機能と安全性の評価 [Preprint]. Jxiv, JST preprint server.

Ikemoto, K. (2025). 長寿物質(老化を抑制する物質) [Preprint]. Jxiv, JST preprint server.

Tamakoshi, M., Suzuki, T., Nishihara, E., Nakamura, S., & Ikemoto, K. (2023). Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults. Food & Function.

Ikemoto, K., Imaruoka, S., & Mohamad Ishak, N. S. (2023). From the kitchen to the lab: Discovery and application of food catalysts to promote the coupling of quinone with amines [Preprint].

Mohamad Ishak, N. S., Numaguchi, T., & Ikemoto, K. (2023). Antiviral effects of pyrroloquinoline quinone through redox catalysis to prevent coronavirus infection. ACS Omega.

Tsuji, S., Ikemoto, K., & Akagawa, M. (2022). PQQの体脂肪減少機能 [Preprint]. Jxiv, JST preprint server.

Mohamad Ishak, N. S., Ikemoto, K., Kikuchi, M., Ogawa, M., Akutagawa, K., & Akagawa, M. (2021). Pyrroloquinoline quinone attenuates fat accumulation in obese mice fed with a high-fat diet, Daphnia magna supplied with a high amount of food, and 3T3-L1 adipocytes. ACS Food Science & Technology.

Saihara, K., Kamikubo, R., Ikemoto, K., Uchida, K., & Akagawa, M. (2017). Pyrroloquinoline quinone, a redox-active o-quinone, stimulates mitochondrial biogenesis by activating the SIRT1/PGC-1α signaling pathway. Biochemistry.

Ikemoto, K., Sakamoto, Y., Tanaka, R., Ogata, K., Matsushita, N., & Nakamura, S. (2017). Unusual ionic bond and solubility mechanism of NanPQQ (n = 0–4) crystals. Crystal Growth & Design.

Panpan Hou | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Assist. Prof. Dr. Panpan Hou | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

Macau University Of Science And Technology | Macau

Assist. Prof. Dr. Panpan Hou is a distinguished researcher in the field of Biomedical Engineering and Biophysics, with a prolific record of 375 documents, 541 citations, and an h-index of 16. After obtaining a B.S. in Biomedical Engineering and a Ph.D. in Biophysics from Huazhong University of Science and Technology, Dr. Hou completed postdoctoral training at Washington University in St. Louis before joining Macau University of Science and Technology as an Assistant Professor in 2021. Dr. Hou’s research focuses on ion channel physiology, voltage-sensor domain (VSD) mechanisms, and electro-mechanical coupling, elucidating complex molecular processes such as the VSD-pore coupling in KCNQ1 channels and identifying novel modulators with therapeutic potential. He has made significant contributions to drug screening, cardiovascular disease modeling, and electrophysiology, publishing high-impact work in journals including Nature Communications, PNAS, eLife, Circulation Research, and Scientific Reports. Dr. Hou has received multiple awards including the AHA Postdoctoral Fellowship, Best Poster Awards at international symposia, and the 2025 Best Research Output Award from Macau University of Science and Technology. Beyond research, he actively mentors students, serves on editorial boards, and contributes to national and international scientific societies. With a strong track record of innovation, mentorship, and high-impact publications, Dr. Hou exemplifies excellence in biomedical research and is poised to advance the understanding of ion channel physiology and therapeutic interventions.

Profiles : Scopus | Orcid | Google Scholar

Featured Publications

Zhong, L., Lin, X., Cheng, X., Wan, S., Hua, Y., Nan, W., Hu, B., Peng, X., Zhou, Z., Zhang, Q., Yang, H., Noé, F., Yan, Z., Jiang, D., Zhang, H., Liu, F., Xiao, C., Zhou, Z., Mou, Y., Yu, H., Ma, L., Huang, C., Wong, V. K. W., Chung, S. K., Shen, B., Jiang, Z.-H., Neher, E., Zhu, W., Zhang, J., & Hou, P. (2025). Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating. Cell Research.

Hou, P., Zhao, L., Zhong, L., Shi, J., Wang, H. Z., Gao, J., Liu, H., Zuckerman, J., Cohen, I. S., & Cui, J. (2024). The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response. PNAS Nexus.

Liu, Y., Xu, X., Gao, J., Naffaa, M. M., Liang, H., Shi, J., Wang, H. Z., Yang, N.-D., Hou, P., & Zhao, W. (2022). Author correction: A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation. Communications Biology.

Dou, A., Kang, P. W., Hou, P., Zaydman, M. A., Zheng, J., Jegla, T., & Cui, J. (2021). Principles of sensor-effector organization in six-transmembrane ion channels.

Lin, Y., Grinter, S. Z., Lu, Z., Xu, X., Wang, H. Z., Liang, H., Hou, P., Gao, J., Clausen, C., & Shi, J. (2021). Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects. Proceedings of the National Academy of Sciences.

Liu, Y., Xu, X., Gao, J., Naffaa, M. M., Liang, H., Shi, J., Wang, H. Z., Yang, N.-D., Hou, P., & Zhao, W. (2020). A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation. Communications Biology.

Taylor, K. C., Kang, P. W., Hou, P., Yang, N.-D., Kuenze, G., Smith, J. A., Shi, J., Huang, H., McFarland White, K., & Peng, D. (2020). Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. eLife.

Hou, P., Kang, P. W., Kongmeneck, A. D., Yang, N.-D., Liu, Y., Shi, J., Xu, X., McFarland White, K., Zaydman, M. A., Kasimova, M. A., Seebohm, M., Zhong, L., Zou, X., Tarek, M., & Cui, J. (2020). Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation. Nature Communications.

Zhu, W., Mazzanti, A., Voelker, T. L., Hou, P., Moreno, J. D., Angsutararux, P., Naegle, K. M., Priori, S. G., & Silva, J. R. (2019). Predicting patient response to the antiarrhythmic mexiletine based on genetic variation: Personalized medicine for long QT syndrome. Circulation Research.

Hou, P., Kang, P. W., Kongmeneck, A. D., Yang, N.-D., Liu, Y., Shi, J., Xu, X., McFarland White, K., Zaydman, M. A., Kasimova, M. A., Seebohm, M., Zhong, L., Zou, X., Tarek, M., & Cui, J. (2019). Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activation.

Hou, P., Shi, J., McFarland White, K., Gao, Y., & Cui, J. (2019). ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling. eLife.

Hou, P., Shi, J., McFarland White, K., Gao, Y., & Cui, J. (2019). ML277 specifically enhances pore opening of KCNQ1 with VSD at the activated state by modulating VSD-pore coupling.

Hou, P., Eldstrom, J., Shi, J., Zhong, L., McFarland, K., Gao, Y., Fedida, D., & Cui, J. (2017). Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening. Nature Communications.

Shadab Ahamad | Biochemistry, Genetics and Molecular Biology | Best Scholar Award

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Mr. Shadab Ahamad | Biochemistry, Genetics and Molecular Biology | Best Scholar Award

Sri Sathya Sai University for Human Excellence | India

Mr. Shadab Ahamad is a dedicated life sciences researcher specializing in biotechnology, genomics, and congenital heart disease (CHD) studies. He is currently pursuing a Ph.D. in Life Sciences at Sri Sathya Sai University for Human Excellence, focusing on unraveling genetic and environmental factors contributing to CHD through advanced genomic approaches such as GWAS, NGS, and variant screening. His academic background includes a B.Tech. in Biotechnology from GB Pant University of Agriculture and Technology, a DBT-sponsored Postgraduate Diploma in Agricultural Biotechnology from Amity Institute of Biotechnology, and research fellowships across prestigious institutes including JNCASR and IARI Delhi. Professionally, he serves as a Research Officer at Sri Sathya Sai Sanjeevani International Centre for Child Heart Care and Research, where he integrates clinical data analysis with genomic research to explore genotype-phenotype correlations and maternal-perinatal risk factors. His work spans plant biotechnology, nanotechnology integration, and clinical genomics, with multiple peer-reviewed research articles, reviews, and book chapters. Having presented at numerous international conferences and received recognition for his contributions, Mr. Ahamad continues to bridge translational research and clinical application to improve child health outcomes globally.

Profile : Orcid

Featured Publications

  • "Maternal Peri-Conceptional Sleep Quality and Risk of Congenital Heart Disease in Offspring: An Exploratory Case–Control Study"

  • "Developmental Origins of Health and Disease"

  • "Impact of long-term deep freeze storage on human leukocytes viability & DNA extraction: Insights from a resource-limited biorepository"

  • "Navigating Life with Rare Syndromes and Congenital Heart Disease: The Unseen Link"

  • "Is Poor Maternal Sleep Quality in the Periconceptional Period a Risk Factor for Congenital Anomalies in Offspring?"

  • "Systematic molecular view of targets prioritization of congenital heart disease against developmental toxicity"

  • "Paternal Teratogen Exposure and Risk of Congenital Heart Disease in Offspring: A Two-Year Retrospective Observational Study"

  • "Summary of initiatives for treating congenital heart disease: Enhancing quality of life and bridging the knowledge gap"

  • "Computational insights into maternal environmental pollutants and folate pathway regulation"

  • "Isolation and PCR Validation of DNA from Chicory (Cichorium intybus L.) Leaves Using an Optimized CTAB Method to Propel Medicinal Insights"

Adarsh Kumar Shukla | Pharmacology, Toxicology and Pharmaceutical Science | Best Researcher Award

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Dr. Adarsh Kumar Shukla | Pharmacology, Toxicology and Pharmaceutical Science | Best Researcher Award

Dr. Bhimrao Ramji Ambedkar Government Medical College | India

Author Profile

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Early Academic Pursuits

Dr. Adarsh Kumar Shukla laid the foundation of his academic journey with a strong inclination towards life sciences and biological research. Beginning with a degree in Biotechnology, he cultivated a passion for understanding molecular processes and biological systems. His interest in computational and applied biological sciences further deepened during his Master’s studies in Bioinformatics, where he explored the integration of biology with computational technologies. This academic progression culminated in a doctoral degree in Nutrition Biology from the Central University of Haryana, where he investigated nutraceutical compounds, molecular therapeutics, and bioinformatics-based approaches to health and nutrition. His early academic pursuits reflect a strong balance between theoretical learning, laboratory training, and computational applications in life sciences.

Professional Endeavors

Dr. Shukla’s professional career demonstrates a consistent alignment with advanced biomedical research and innovation. He began as a Research Associate and later served as a Scientist in the Department of Paediatric Cardiac Research at Sri Sathya Sai Sanjeevani Research Foundation, contributing to projects on congenital heart diseases and molecular mapping of environmental toxicants. His current role as Scientist-B in the Multidisciplinary Research Unit at Dr. Bhimrao Ramji Ambedkar Government Medical College, Kannauj, highlights his continued commitment to translational biomedical research. Alongside, he has engaged in teaching and faculty development programs, coordinated national scientific conclaves, and participated in capacity-building initiatives in healthcare and nutrition sciences.

Contributions and Research Focus

Dr. Shukla’s research spans a wide spectrum, encompassing structural bioinformatics, human genomics, and nutritional biology. His investigations range from identifying novel bioactive compounds in millets and medicinal plants to computationally mapping toxicants responsible for congenital disorders. His work on psychobiotics and gut-brain regulation has added new insights into neuropsychological health, while his contributions in plant-informatics shed light on the therapeutic potential of natural compounds against viral and bacterial diseases. Additionally, his focus on food-informatics and nutrigenomics has emphasized the role of probiotics, dietary fibers, and bioengineered foods in human health. Through a combination of in-silico and in-vitro studies, his work bridges computational biology with clinical and nutritional sciences.

Accolades and Recognition

Over the course of his career, Dr. Shukla has been recognized for his scientific excellence through awards, patents, and international presentations. He achieved distinction at global scientific forums, securing recognition for his molecular insights into congenital heart disease. His granted Indian patent on crab-apple-based jelly sheets demonstrates his inventive ability to connect traditional resources with modern food biotechnology. Furthermore, his peer-review contributions for high-impact journals and invited roles as a book reviewer underline his standing in the academic community. These achievements illustrate his ability to merge innovation with scholarly rigor.

Impact and Influence

The impact of Dr. Shukla’s research is evident in the interdisciplinary nature of his contributions. His computational models for drug discovery, therapeutic peptides, and congenital heart disease targets provide frameworks for future translational research. His coordination of events such as National Nutrition Month and Women in STEM conclaves reflects his commitment to societal awareness and academic empowerment. By blending computational biology with real-world health challenges, he has influenced research directions in reproductive toxicology, nutraceutical development, and environmental genomics, thereby shaping both scientific knowledge and public health practices.

Legacy and Future Contributions

Dr. Shukla’s academic and professional trajectory reflects the making of a researcher whose work is deeply rooted in societal relevance and interdisciplinary innovation. His legacy lies in advancing computational nutrition biology and medical informatics to address complex health challenges. Looking ahead, his ongoing projects on congenital heart disease, exposome mapping, and nutratherapeutics hold the promise of contributing to precision medicine and sustainable food innovations. His future contributions are likely to expand the integration of bioinformatics with clinical sciences, reinforcing his role as a bridge between molecular insights and healthcare applications.

Present Affiliation

Dr. Adarsh Kumar Shukla is currently serving as Scientist-B in the Multidisciplinary Research Unit at Dr. Bhimrao Ramji Ambedkar Government Medical College, Kannauj, Uttar Pradesh. His role reflects his dedication to advancing multidisciplinary biomedical research with a focus on translational outcomes for healthcare.

Publications

Article: Computational insights into maternal environmental pollutants and folate pathway regulation
Authors: Adarsh Kumar Shukla, Shadab Ahamad, Prachi Kukshal
Journal: Reproductive Toxicology
Year: 2025

Article: Virtual screening of potential orally active anti-bacterial compounds of finger millet
Authors: Raushan Kumar Jha, Adarsh Kumar Shukla, Anita Kumari, Ashwani Kumar
Journal: Vegetos
Year: 2024

Article: Identification of micronutrient deficiency related miRNA and their targets in Triticum aestivum using bioinformatics approach
Authors: Surbhi Panwar, Sunita Pal, Adarsh Kumar Shukla, Ashwani Kumar, Pradeep Kumar Sharma
Journal: Ecological Genetics and Genomics
Year: 2024

Article: Effect of processing techniques on functional, antioxidants, and structural properties of finger millet (Eleusine coracana) flour
Authors: Arzoo, Neeru, Adarsh Kumar Shukla, Surbhi Panwar, Ashwani Kumar
Journal: Food and Humanity
Year: 2024

Article: Nutritional evaluation of probiotics enriched rabadi beverage (PERB) and molecular mapping of digestive enzyme with dietary fibre for exploring the therapeutic potential
Authors: Prakash Yadav, Adarsh Kumar Shukla, Deepika, Neeru, Anita Kumari, Tejpal Dhewa, Ashwani Kumar
Journal: Food and Humanity
Year: 2024

Conclusion

In summary, Dr. Shukla embodies the qualities of a multidisciplinary scientist who blends innovation with social responsibility. His research not only advances scientific understanding but also carries tangible implications for human health and nutrition. With his current role in a government medical research unit and his wide-ranging expertise, he is poised to make enduring contributions to biomedical sciences, food biotechnology, and public health.