Zhu Jingyi | Cataract | Excellence in Research Award

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Dr. Zhu Jingyi | Cataract | Excellence in Research Award

The General Hospital of Central Theater Command | China

Dr. Zhu Jingyi is an emerging researcher in vision science and ophthalmic biology, with a focused research profile encompassing retinal pathophysiology, neuroprotection, and molecular mechanisms of ocular diseases. The scholarly output comprises 8 research documents, which have received 89 citations from 87 citing publications, yielding an h-index of 6, reflecting growing academic impact. The research explores cellular and metabolic responses in glaucoma, retinal ischemia–reperfusion injury, and optic nerve damage, with particular emphasis on water transport regulation, ferroptosis, oxidative stress, and energy metabolism in retinal cells. Significant contributions include studies on AQP1-mediated lens physiology, DJ-1–saRNA–based nucleic acid delivery systems for retinal protection, and signaling pathways such as Rap1, YAP/TAZ, and Warburg-like glycolysis in retinal ganglion cell survival. This body of work advances mechanistic understanding and therapeutic strategies for degenerative and ischemic eye diseases.

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Chaoyang Zhang | Medicine and Dentistry | Best Researcher Award

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Dr. Chaoyang Zhang | Medicine and Dentistry | Best Researcher Award

The Primasia International Eye Research Institute of The Chinese University of Hong Kong | China

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🎓 Early Academic Pursuits

Dr. Zhang began his academic journey with a Bachelor's degree in Animal Science from Shihezi University in 2013. Inspired to pursue clinical science, he undertook a Ph.D. in Clinical Medicine at Tongji University, completing his doctoral studies in 2020 under the guidance of Professors Guo-Tong Xu and Jingfa Zhang. His doctoral training laid a robust foundation for translational research in ophthalmology.

💼 Professional Endeavors

Following his Ph.D., Dr. Zhang served as an Assistant Research Fellow at the Department of Ophthalmology, Shanghai General Hospital (Shanghai Jiao Tong University School of Medicine), from 2020 to 2024. In this role, he also functioned as Scientific Secretary, actively contributing to the National Clinical Research Center for Eye Diseases. Since September 2024, he has held the position of Associate Research Fellow at The Primasia International Eye Research Institute of the Chinese University of Hong Kong (Shenzhen), where he continues to push the frontiers of ophthalmic research.

🔬 Contributions and Research Focus

Dr. Zhang’s research centers on the pathogenesis and treatment of diabetic retinopathy, diabetic macular edema, and subretinal fibrosis in neovascular age-related macular degeneration. His scientific approach integrates molecular biology, pharmacology, and clinical ophthalmology.

He has authored over 10 high-impact publications as first or co-first author in Q1 journals such as Pharmacological Research, Phytomedicine, and Investigative Ophthalmology & Visual Science. His works explore:

  • Roles of Aquaporin 11 in Müller cell water transport and retinal edema
  • Anti-fibrotic effects of Luteolin via Smad2/3 and YAP pathways
  • γ-Secretase inhibition as a therapeutic target for subretinal fibrosis
  • Erythropoietin's role in maintaining the blood-retinal barrier

His current research is supported by a Youth Program Grant from the National Natural Science Foundation of China, exploring AQP11-ERS-ATF4 axis signaling in diabetic retinopathy.

 

🏅 Accolades and Recognition

Dr. Zhang holds a national patent on Aquaporin11 expression enhancement and is a named researcher on multiple national-level grant projects. His contributions have been recognized through:

  • Prestigious funding from NSFC Youth and General Programs
  • Active membership in the Shanghai Medical Association’s Visual Research Group
  • Peer reviewer roles for high-impact journals like iScience and International Immunopharmacology

🌐 Impact and Influence

Dr. Zhang is a valued member of China’s ophthalmic research community, bridging fundamental science with clinical application. His collaborations with prominent institutions and ongoing contributions to professional societies highlight his growing influence. He has served as an academic reviewer and an integral part of collaborative multi-institutional research on vision-threatening disease

🌟 Legacy and Future Contributions

Looking ahead, Dr. Chaoyang Zhang is poised to redefine therapeutic strategies for vision impairment. His interdisciplinary research, blending genetics, pharmacology, and clinical trials, positions him to make enduring contributions to global eye health. With a strong portfolio of publications, active grants, and a forward-thinking approach, Dr. Zhang represents the future of translational ophthalmology.

 

Publications

📄 Nintedanib Inhibits Neovascularization and Subretinal Fibrosis in a Laser-Induced Choroidal Neovascularization Mouse Model
Authors: Shiyue Qin, Yingying Zhu, Yinping Liu, Hai Xie, Jingfa Zhang, Chaoyang Zhang, Guoxu Xu
Journal: Biochemical and Biophysical Research Communications
Year: 2025

📄 Glucose transport, transporters and metabolism in diabetic retinopathy
Authors: Chaoyang Zhang, Gu L., Xie H., Liu Y., Huang P., Zhang J., Luo D., Zhang J.
Journal: Biochimica et Biophysica Acta - Molecular Basis of Disease
Year: 2024

📄 Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration
Authors: Dandan Liu, Jingxiao Du, Hai Xie, Haibin Tian, Lixia Lu, Chaoyang Zhang, Guo-Tong Xu, Jingfa Zhang
Journal: Journal of Neuroinflammation
Year: 2024

📄 Application and prospect of gene therapy for fundus vascular diseases (基因治疗在眼底血管性疾病中的应用和展望)
Authors: Chaoyang Zhang, Jingxiang Zhang, Jingfa Zhang
Journal: International Eye Science
Year: 2023

📄 Aquaporin 11 alleviates retinal Müller intracellular edema through water efflux in diabetic retinopathy
Authors: Chaoyang Zhang, Dong Luo, Hai Xie, Qian Yang, Dandan Liu, Liang Tang, Jian Zhang, Weijia Li, Haibin Tian, Lixia Lu, Xiaodong Sun, Guo-Tong Xu, Jingfa Zhang
Journal: Pharmacological Research
Year: 2023

Peng Chen | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Prof. Peng Chen | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

Qingdao University | China

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Early Academic Pursuits 🎓

Prof. Peng Chen's journey in medical research began with a strong foundation in clinical medicine and biomedical sciences. She earned her Bachelor of Medicine degree from Taishan Medical College (1999-2004), where she gained essential medical knowledge and clinical training. Her pursuit of advanced expertise led her to Capital University of Medical Sciences (2004-2007), where she obtained a Master of Science degree, focusing on medical research methodologies and specialized clinical studies. To further deepen her understanding and expertise, she pursued a Doctor of Medicine (2009-2012) at Qingdao University, refining her specialization in ophthalmology and regenerative medicine.

Professional Endeavors 🔬

After completing her master's degree, Prof. Chen embarked on her professional career at the Shandong Eye Institute (2007-2016), a renowned institution dedicated to ophthalmology research. During her tenure, she made significant contributions to vision sciences and ocular disease research, strengthening her expertise in eye-related disorders. In 2016, she transitioned to Qingdao University, where she currently serves as a leading researcher and faculty member. Her role at the university allows her to conduct cutting-edge research on ophthalmology and liver regeneration, mentor young medical scientists, and contribute to the advancement of medical science.

Contributions and Research Focus 🔍

Prof. Chen's research has significantly impacted liver regeneration, macrophage efferocytosis, and ophthalmology, particularly in understanding cellular mechanisms and disease pathophysiology. Some of her key contributions include:

  • Liver Regeneration and Macrophage Efferocytosis: Her recent studies have explored the NLRP3 inflammasome's role in constraining liver regeneration by impairing macrophage efferocytosis (Sci Adv., 2025). Additionally, she has investigated the role of Aquaporin-5 in facilitating liver regeneration via the ROS/GSDMD pathway (Cell Signal., 2025) and how extracellular vesicles containing GAS6 protect the liver from ischemia-reperfusion injury (Cell Death Discov., 2024).
  • Ophthalmology and Ocular Disease Research: She has studied the retinoic acid synthesis pathway in AQP5-deficient mice and its implications for dry eye disease (Invest Ophthalmol Vis Sci., 2024). Her research has also examined the regulation of axon guidance by Slit2 and Netrin-1 signaling in lacrimal gland development (Invest Ophthalmol Vis Sci., 2023).

Prof. Chen’s research not only deepens scientific knowledge in these areas but also paves the way for novel therapeutic strategies for liver and eye diseases.

Accolades and Recognition 🏆

Prof. Chen’s contributions to medical science have been widely recognized through prestigious research grants and peer-reviewed publications. She has received:

  • National Natural Science Foundation of China (2020-2023): RMB 550,000 for research on AQP5’s protective role in lens transparency through miRNA-mediated autophagy.
  • Shandong Provincial Natural Science Foundation (2018-2021): RMB 150,000 for the identification and functional study of Fuchs corneal endothelial dystrophy gene.

Her research has been featured in top-tier scientific journals, including Science Advances, Cell Signal, Cell Death Discovery, and Investigative Ophthalmology & Visual Science, reinforcing her status as a leading expert in regenerative medicine and ophthalmology.

Impact and Influence 🌍

Prof. Chen’s work bridges fundamental research and clinical applications, making a profound impact in both ophthalmology and liver disease treatment. Her findings on macrophage efferocytosis and aquaporins have opened new avenues for therapeutic interventions in liver regeneration, while her contributions to ocular disease mechanisms have enhanced the understanding of corneal and lacrimal gland pathophysiology.

Through her mentorship, collaborations, and academic contributions, she continues to shape the next generation of medical researchers and clinicians, strengthening Qingdao University’s reputation as a hub for medical research excellence.

Legacy and Future Contributions 🚀

With an established track record in liver regeneration and ophthalmic research, Prof. Peng Chen’s future contributions are expected to drive medical innovations in regenerative medicine and precision healthcare. Her work on cellular signaling pathways, extracellular vesicles, and aquaporins will likely inspire new therapeutic breakthroughs in both systemic and ocular diseases. As she continues to lead cutting-edge research, mentor young scientists, and contribute to transformative discoveries, Prof. Chen’s legacy will be one of scientific excellence, innovation, and meaningful impact on global healthcare.

Publications

  • 📄NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis

    • Journal: Science Advances
    • Year: 2025
    • Authors: Wei S, Guan G, Luan X, Yu C, Miao L, Yuan X, Chen P*, Di G*

  • 📄Aquaporin-5 facilitates liver regeneration following hepatectomy via ROS/GSDMD pathway

    • Journal: Cell Signaling
    • Year: 2025
    • Authors: Li B, Di G, Ge H, Song P, Han W, Sun H, Wang D, Chen P*, Wang Y*

  • 📄Extracellular vesicles containing GAS6 protect the liver from ischemia-reperfusion injury by enhancing macrophage efferocytosis via MerTK-ERK-COX2 signaling

    • Journal: Cell Death Discovery
    • Year: 2024
    • Authors: Miao L, Yu C, Guan G, Luan X, Jin X, Pan M, Yang Y, Yan J, Chen P*, Di G*

  • 📄Reticulated Retinoic Acid Synthesis is Implicated in the Pathogenesis of Dry Eye in Aqp5 Deficiency Mice

    • Journal: Investigative Ophthalmology & Visual Science
    • Year: 2024
    • Authors: Ge H, Di G, Li B, Han W, Song P, Han S, Wang D*, Chen P*

  • 📄Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice

    • Journal: Investigative Ophthalmology & Visual Science
    • Year: 2023
    • Authors: Bai Y, Di G, Ge H, Li B, Zhang K, Zhang D, Wang D*, Chen P*

 

Yanhua Wang | Medicine and Dentistry | Best Researcher Award

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Dr. Yanhua Wang | Medicine and Dentistry | Best Researcher Award

Shanxi Aier Eye Hospital | China

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Early Academic Pursuits 📚

Dr. Yanhua Wang's journey in ophthalmology began with her Bachelor's degree in Clinical Medicine from Shanxi Changzhi Medical University in 1998. She pursued advanced studies, earning an MD in Ophthalmology and a PhD from Southwest Eye Hospital, General Medical University in Chongqing, China. Her academic trajectory was further enriched with a postdoctoral fellowship at the Department of Ophthalmology, General Hospital of PLA, Beijing, in 2013. This solid foundation equipped her with expertise in cutting-edge ophthalmic research and clinical care.

Professional Endeavors 💼

Dr. Wang's career spans over two decades, marked by her tenure as Deputy Chief Physician at Jinhzhong Hospital, Shanxi Province, where she served until 2016. Currently, she is the Chief Physician at the Department of Pediatric Ophthalmology & Optometry, Shanxi Aier Eye Hospital, part of the Aier Eye Hospital Group. Her role emphasizes innovative treatments and advanced care for pediatric ocular conditions, solidifying her as a leader in her field.

Contributions and Research Focus 🧠🔬

Dr. Wang’s research delves into the mechanisms underlying retinal neuron survival, optic nerve regeneration, and pediatric strabismus. Her studies on alpha-crystallin’s neuroprotective effects and its role in axonal regeneration have pioneered new therapeutic pathways. Through publications in journals such as Journal of Ophthalmology and Neuroscience Letters, she has significantly advanced understanding in these domains. She has also innovated patented technologies, including intelligent examination devices and surgical support structures, showcasing her dedication to translational research.

Accolades and Recognition 🏆

Dr. Wang has received numerous accolades, including the Chongqing Second Prize for Scientific and Technological Progress in 2013. She has secured major grants from prestigious institutions, such as the National Natural Science Foundation of China, the China Postdoctoral Science Foundation, and the Aier Eye Hospital Group Foundation. These honors reflect her impactful contributions to ophthalmology and translational medicine.

Impact and Influence 🌍

Dr. Wang’s work has had a profound influence on pediatric ophthalmology, offering novel diagnostic and therapeutic solutions for conditions like strabismus. Her patented inventions have enhanced clinical precision and patient outcomes, and her research has provided valuable insights into neuroprotection and nerve regeneration. Her leadership in clinical care and her scientific achievements continue to inspire and guide the next generation of ophthalmologists.

Legacy and Future Contributions 🌟

With her unwavering commitment to pediatric ophthalmology and groundbreaking research, Dr. Yanhua Wang's legacy is one of innovation and compassion. Her future contributions promise to bridge clinical advancements with cutting-edge research, ensuring better ocular health outcomes for children worldwide. Through her continued efforts, Dr. Wang is poised to leave an indelible mark on ophthalmology and medical science.

 

Publications

📝 Characteristics of Peripheral Retinal Refraction and Its Role in Children with Different Refractive States
Authors: Qi Zhao, Yanhua Wang*, Tiangang Liang, Weixiang Nie, Pei Xue, Jie Cheng
Journal: Journal of Ophthalmology
Year: 2024

📝 Synergistic Effect of Olfactory Ensheathing Cells and Alpha-Crystallin on Restoration of Adult Rat Optic Nerve Injury
Authors: Wang, Y.H., Yin, Z.Q., Wang, Y.
Journal: Neuroscience Letters
Year: 2017

📝 Leber's Hereditary Optic Neuropathy is Associated with Compound Primary Mutations of Mitochondrial ND1 m.3635G > A and ND6 m.14502 T > C
Authors: Jin, X., Wang, L., Gong, Y., Chen, T., Wei, S.
Journal: Ophthalmic Genetics
Year: 2015

📝 Alpha-Crystallin Promotes Rat Olfactory Ensheathing Cells Survival and Proliferation through Regulation of PI3K/Akt/mTOR Signaling Pathways
Authors: Wang, Y.H., Li, Y.C., Huo, S.J., Yin, Z.Q.
Journal: Neuroscience Letters
Year: 2012

📝 Alpha-Crystallin Promotes Rat Axonal Regeneration through Regulation of RhoA/Rock/Cofilin/MLC Signaling Pathways
Authors: Wang, Y.H., Wang, D.W., Wu, N., Wang, Y., Yin, Z.Q.
Journal: Journal of Molecular Neuroscience
Year: 2012