Guoxin Ni | Medicine and Dentistry | Best Researcher Award

Prof. Guoxin Ni | Medicine and Dentistry | Best Researcher Award

First Affiliated Hospital of Xiamen University | China

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🎓 Early Academic Pursuits

Prof. Guoxin Ni embarked on his academic journey with a strong foundation in [specific field], earning his [degree] from [university] in [year]. His early years were marked by an insatiable curiosity and dedication to understanding [relevant subject], which laid the groundwork for his future contributions to academia and research.

🌟 Professional Endeavors

Over the years, Prof. Ni has been associated with esteemed institutions such as [institution names], where he has played a pivotal role in [teaching/research]. As a [current position] at [university/institution], he has been instrumental in shaping the academic landscape, mentoring students, and spearheading research initiatives that push the boundaries of [field of expertise].

🔬 Contributions and Research Focus

Prof. Ni’s research is centered on [key research areas], where he has made groundbreaking discoveries in [specific topic]. His work on [notable research or project] has been widely recognized, contributing significantly to the advancement of [industry/academic field]. His innovative approaches and methodologies have paved the way for new understandings and applications in [related domain].

🏆 Accolades and Recognition

A recipient of numerous awards, Prof. Ni’s excellence has been acknowledged through [list of notable awards and honors]. His contributions have been celebrated in [journals/conferences], and he continues to be a sought-after speaker and expert in his field.

🌐 Impact and Influence

Beyond academia, Prof. Ni has influenced the broader [industry/field] community through collaborations with [organizations/industries]. His work has inspired budding researchers and professionals alike, setting new benchmarks for innovation and excellence. His leadership in [specific initiative or research group] has fostered a culture of exploration and intellectual growth.

💪 Legacy and Future Contributions

Looking ahead, Prof. Ni remains committed to advancing research in [field], with ongoing projects aimed at [future research direction]. His vision and dedication continue to drive progress, ensuring a lasting legacy in both academic and professional circles. His impact will undoubtedly shape the future of [industry or field] for generations to come.

 

Publications


📄 Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis
Authors: Xuchang Zhou, Hong Cao, Tao Liao, Shengyao Liu, Guoxin Ni
Journal: Non-coding RNA Research
Year: 2025


📄 Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection
Authors: Xuchang Zhou, Yajing Yang, Xu Qiu, Donghai Lin, Guoxin Ni
Journal: Journal of Advanced Research
Year: 2025


📄 Translation, Cross-Culture Adaptation and Measurement Properties of the Simplified Chinese Version of the Osteoarthritis Knowledge Scale
Authors: Ziru Wang, Ben Darlow, Huili Deng, Guoxin Ni
Journal: Musculoskeletal Care
Year: 2024


📄 Tetrathiomolybdate alleviates osteoporosis by activating the PI3K/AKT signaling axis
Authors: Xuchang Zhou, C.H. Cao, Dongxue Wang, Shengyao Liu, Guoxin Ni
Journal: European Cells and Materials
Year: 2024


📄 Evaluation of Quantitative and Selective Sensory Fiber Dysfunction in Patients with Cirrhosis
Authors: Nannan Zhang, Zhiyong Wang, Jianmin Chen, Guoxin Ni, Jun Ni
Journal: Current Neurovascular Research
Year: 2024


Inmaculada Gilaberte | Medicine and Dentistry | Best Researcher Award

Dr. Inmaculada Gilaberte | Medicine and Dentistry | Best Researcher Award

FAES Farma | Spain

Author Profile

Scopus

🌱 Early Academic Pursuits

Dr. Inmaculada Gilaberte’s academic journey is rooted in a commitment to excellence and medical advancement. She initially pursued education in clinical research, equipping herself with in-depth knowledge and skills in therapeutic areas such as neuroscience and immunology. Her academic foundation was further strengthened by certifications, including a lecturer certification from the Spanish Quality Register Agency (ANECA), and advanced leadership programs from institutions like Stanford and MIT. These formative experiences shaped her growth mindset, laying the groundwork for a career dedicated to precision, patient-centered care, and effective team collaboration.

💼 Professional Endeavors

Throughout her career, Dr. Gilaberte has held prominent roles in major pharmaceutical companies such as FAES FARMA, Takeda, TiGenix, Roche, and Lilly, with positions spanning from Clinical Research Physician to Director of Clinical Research. She has led various departments, managed global teams, and directed clinical trials across multiple therapeutic areas, including gastroenterology, immunology, cardiology, and pain management. Her strategic guidance has driven several landmark projects forward, including the advancement of microbiome and cell therapies from preclinical to first-in-human trials, demonstrating her expertise in transforming innovative therapies into viable treatment options.

🧬 Contributions and Research Focus

Dr. Gilaberte has made notable contributions to clinical research, particularly in stem cell therapy, immunology, and neuroscience. Her pioneering work on Darvadstrocel, an allogeneic adipose-derived mesenchymal stem cell therapy, led to significant strides in treating perianal fistulas and positioned her as a leader in regenerative medicine. She has been instrumental in launching global clinical trials, developing target product profiles (TPP), and submitting regulatory applications for FDA and EMA approvals. With a robust publication record, including 66 papers indexed in PubMed, she continues to contribute to scientific literature, sharing her findings and advancing the field of biomedicine.

🏆 Accolades and Recognition

Dr. Gilaberte’s excellence has been recognized through numerous awards across her roles in clinical development and leadership. Her achievements include multiple awards for her work in the clinical progression of innovative therapies and successful drug submissions to global regulatory bodies. She has received recognition for her strategic contributions to the Darvadstrocel trials and for advancing neuroscience programs in Alzheimer’s disease. Her leadership has earned her high regard in the industry, with acknowledgments from institutions and colleagues alike.

🌍 Impact and Influence

Dr. Gilaberte’s impact extends beyond her immediate professional roles. Her contributions to clinical science have enhanced treatment options for patients with complex diseases, and her leadership has shaped clinical strategies in multinational pharmaceutical companies. She has also promoted effective collaboration across global, cross-functional teams, fostering a diverse and inclusive work environment that prioritizes patient needs. Her initiatives in regulatory compliance, risk management, and data integration have set new standards for clinical operations, solidifying her influence as a thought leader in her field.

📜 Legacy and Future Contributions

Looking ahead, Dr. Gilaberte’s legacy is one of commitment to advancing patient care through innovation, collaboration, and strategic foresight. Her future endeavors are poised to make an enduring impact, with ongoing research and leadership contributions that will shape the future of clinical development. Her philanthropic work, such as building a nursery in Uganda, highlights her dedication to global well-being beyond her professional achievements. Dr. Gilaberte continues to inspire the next generation of clinical researchers, ensuring that her legacy of precision, empathy, and patient-first innovation will endure.

 

Publications


📄 Efficacy and Safety of Weekly Calcifediol Formulations (75 and 100 µg) in Subjects with Vitamin D Deficiency: A Phase II/III Randomised Trial

  • Authors: Esteban Jódar-Gimeno, Jose Luis Pérez-Castrillón, Ján Nociar, Michal Lojka, Dimitar Nikolov, Fernando Cereto-Castro, Snežana Novković, Umberto Tarantino, Nadia Mehsen-Cetre, Paula Arranz, Cristina Martínez Ostalé, Aintzane García-Bea, Inmaculada Gilaberte
  • Journal: Nutrients
  • Year: 2024

📄 Comparative inhibition by oral bilastine, parenteral dexchlorpheniramine, and a new bilastine parenteral (i.v. and i.m.) formulation of histamine-induced wheal and flare response: A randomised phase I trial

  • Authors: Coimbra, J., Puntes, M., Molina, P., Arranz, P., Sánchez, C.
  • Journal: European Journal of Pharmaceutical Sciences
  • Year: 2024

📄  Bioequivalence and Safety of Bilastine 20 mg Orodispersible Tablets and Conventional Tablets: A Randomized, Single-Dose, Two-Period Crossover Study in Healthy Volunteers Under Fasting Conditions

  • Authors: Román, M., Ochoa, D., Martin, S., Arranz, P., Sánchez, C.
  • Journal: Drugs in R and D
  • Year: 2024

📄  Disease Burden, Treatment Patterns, and Economic Impact of Rectovaginal Fistulas in Patients with Crohn’s Disease: Findings from a Retrospective, Observational, Longitudinal Study Based on US Claims Databases

  • Authors: Karki, C., Latremouille-Viau, D., Gilaberte, I., Romdhani, H., Lightner, A.L.
  • Journal: PharmacoEconomics
  • Year: 2023

📄  Follow-up Study to Evaluate the Long-term Safety and Efficacy of Darvadstrocel (Mesenchymal Stem Cell Treatment) in Patients With Perianal Fistulizing Crohn’s Disease: ADMIRE-CD Phase 3 Randomized Controlled Trial

  • Authors: Garcia-Olmo, D., Gilaberte, I., Binek, M., Spinelli, A., Panés, J.
  • Journal: Diseases of the Colon and Rectum
  • Year: 2022

 

Tsheten Tsheten | Health Professions | Best Researcher Award

Dr. Tsheten Tsheten | Health Professions | Best Researcher Award

Australian National University | Australia

Author Profile

Orcid

Early Academic Pursuits

Dr. Tsheten began his academic journey with a Bachelor's in Allied Health Sciences from Sri Ramachandra University, India. He later pursued a Master of Public Health at Mahidol University, Thailand. His academic prowess led him to complete a Ph.D. in Epidemiology and Population Health at the Australian National University (ANU) in 2023.

Professional Endeavors

Dr. Tsheten has a rich professional background. Prior to his current role as a Research Fellow at the Population Health Exchange (PHXchange) at ANU, he served as an epidemiologist at the Royal Centre for Disease Control in Bhutan until 2019. His experiences include outbreak investigations, public health, and geospatial mapping.

Contributions and Research Focus

His research interests encompass infectious diseases, neglected tropical diseases, outbreak investigation, and geospatial mapping. Dr. Tsheten's significant contributions include risk mapping and socio-ecological drivers of soil-transmitted helminth infections. He is involved in dengue control strategies, spatial analysis of epidemiological data, and has presented at various international conferences.

Accolades and Recognition

Dr. Tsheten has received accolades such as the Dean's Rising Star Award at ANU. His research on risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines has been recognized. He has secured multiple research grants and is actively engaged in peer-review activities for reputed journals.

Impact and Influence

As a Research Fellow, Dr. Tsheten plays a pivotal role in teaching and mentoring. He serves as a course convener, guest lecturer, and research supervisor. His influence extends to research mentoring for Ph.D. candidates and providing training to health researchers in Bhutan.

Legacy and Future Contributions

Dr. Tsheten's legacy lies in his comprehensive research portfolio, impactful publications, and significant contributions to public health in Bhutan. His future contributions are anticipated through ongoing research, mentoring, and endeavors to control diseases like dengue in the Asia-Pacific region.

Notable Publications

Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling study 2023

Demographic risk factors for extra-pulmonary tuberculosis: a rising public health threat in Bhutan 2023

Impact of COVID-19 on mental health in Bhutan: a way forward for action 2023 (2)

A cross-sectional study to assess the epidemiological situation and associated risk factors of dengue fever; knowledge, attitudes, and practices about dengue prevention in Khyber Pakhtunkhwa Province, Pakistan 2022 (11)

Risk Factors of Symptomatic COVID-19 in Samtse District, Bhutan 2022 (3)

 

 

Kanbiro Gedeno | Health Professions | Editorial Board Member

Mr. Kanbiro Gedeno | Health Professions | Editorial Board Member

Arba Minch University | Ethiopia

Author Profile

Orcid

Early Academic Pursuits

Kanbiro Gedeno Gelebo embarked on his academic journey at the University of Gondar, where he earned his bachelor's degree in Anesthesia in 2018. This marked the beginning of his exploration into the realm of anesthesia.

Professional Endeavors

In 2019, Kanbiro transitioned to Arba Minch University, joining the Department of Anesthesia. Here, he delved into academic activities, laying the foundation for his future contributions to the field.

Contributions and Research Focus

With two years of dedicated academic engagement at Arba Minch University, Kanbiro furthered his expertise by enrolling in the postgraduate class at Dilla University. His focus shifted to Advanced Clinical Anesthesia, a testament to his commitment to advancing his skills and knowledge in the field.

Accolades and Recognition

Kanbiro Gedeno Gelebo's commitment to excellence and rigorous academic pursuit resulted in high academic ranks upon graduating with a postgraduate degree in Advanced Clinical Anesthesia from Dilla University in 2023.

Impact and Influence

During his four years in the academic arena, Kanbiro's influence has been felt through his contributions to the field of Anesthesia. His dedication to learning and research has left a positive impact on his peers and the academic community.

Legacy and Future Contributions

As an Academician and Researcher, Kanbiro's legacy is characterized by a relentless pursuit of knowledge and a dedication to the advancement of clinical anesthesia. Looking forward, he is poised to make significant contributions to the field through continued research, teaching, and mentorship at Arba Minch University. His journey serves as an inspiration for future generations in the field of anesthesia.

Notable Publications

The Impact of Preoperative abnormal Electrocardiography on Anesthesia management among older surgical patients in southern Ethiopia: Prospective cohort study 2023

The effect of preoperative anemia on perioperative outcomes among patients undergoing emergency surgery: A multicenter prospective cohort study 2023

 

 

Christian Pfister | Medicine and Dentistry | Excellence in Research Award

Prof. Christian Pfister | Medicine and Dentistry | Excellence in Research Award

Rouen University Hospital | France

Author Profile

Scopus

Early Academic Pursuits

Prof. Christian Pfister's academic journey commenced with a focus on urology at Charles Nicolle University Hospital in Rouen, France. His early academic pursuits involved comprehensive studies in urological sciences, laying the foundation for a distinguished career in the medical field.

Professional Endeavors

Having established himself as a prominent figure in the field of urology, Prof. Christian Pfister has been associated with the Rouen University Hospital in France. His professional endeavors encompass a wide array of responsibilities within the Department of Urology, where he contributes to patient care, education, and research initiatives.

Contributions and Research Focus

Prof. Pfister's contributions extend beyond clinical practice, with a significant focus on urological research. His research endeavors likely involve advancements in urological treatments, surgical techniques, and potentially groundbreaking discoveries that contribute to the broader medical community's knowledge and understanding.

Accolades and Recognition

Prof. Christian Pfister has likely received accolades and recognition for his outstanding contributions to urology. Recognition may come in the form of awards, honors, or appointments to leadership positions within medical societies, acknowledging his expertise and impact on the field.

Impact and Influence

Prof. Pfister's impact is evident in his influence on the practice of urology, both locally within Rouen University Hospital and potentially on a broader scale. Through his clinical expertise, research contributions, and potential leadership roles, he likely plays a pivotal part in shaping urological practices and advancements.

Legacy and Future Contributions

As a seasoned professional in the field, Prof. Christian Pfister is likely building a lasting legacy in urology. His current contributions, coupled with his dedication to education and patient care, suggest a commitment to leaving a lasting impact on the field. His future contributions may involve mentoring the next generation of urologists and further advancing urological knowledge and treatments.

Notable Publications

Perioperative dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin in muscle-invasive bladder cancer (VESPER): survival endpoints at 5 years in an open-label, randomised, phase 3 study  2023 (1)

Differential impact of COVID-19 on urological surgeries in public and private institutions between 2019 and 2021 in France | Impact du COVID-19 sur l'activité chirurgicale urologique dans les établissements de santé publics et privés entre 2019 et 2021 en France 2023 (1)

Refining the Characterization and Outcome of Pathological Complete Responders after Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer: Lessons from the Randomized Phase III VESPER (GETUG-AFU V05) Trial 2023 (4)

Testicular recurrence of oligometastatic prostatic adenocarcinoma after 22 years of androgen deprivation therapy  2022 (1)

 

Yannick Allanore | Medicine and Dentistry | Best Research Article Award

Prof. Yannick Allanore | Medicine and Dentistry | Best Research Article Award

Université Paris Cité | France

Author Profile

Scopus

Early Academic Pursuits

Yannick Allanore commenced his academic journey at Paris Descartes University, obtaining a Master's degree in 1999, followed swiftly by a Medical Doctor certification in 2000. His commitment to specialization in Rheumatology led to a Certification in Rheumatology in 2001. His profound interest in the field culminated in a thesis on "Oxidative stress and systemic sclerosis," earning him a Physician Doctor title in 2004.

Professional Endeavors

His academic tenure unfolded as an Assistant Professor at Paris Descartes University's Rheumatology department at Cochin Hospital from 2005 to 2008. Allanore's research prowess was acknowledged with a Research Habilitation in 2005, focusing on the pathogenesis of systemic sclerosis. Subsequently, he served as a Post-doctoral researcher at INSERM U781 and U1016, delving into the genetic bases and chronic inflammation of systemic sclerosis.

Contributions and Research Focus

Allanore leads a groundbreaking research team at Institut Cochin, delving into pathogenesis and innovative therapies for fibro-inflammatory rheumatic diseases since 2018. His research delves into genetic and pathophysiological aspects of systemic sclerosis, cardio-pulmonary involvement, clinical trials, and endothelial progenitor cells in rheumatic diseases.

Accolades and Recognition

Professor Allanore boasts a substantial publication record, exceeding 480 papers in peer-reviewed journals, showcasing an impressive H-Index of 71. His contributions have earned him memberships in esteemed societies such as the French Rheumatology Society, American College of Rheumatology, and significant roles within EUSTAR and the World Scleroderma Foundation.

Impact and Influence

His leadership roles, including former chairman of EUSTAR and current vice-director of Institut Cochin, testify to his impact on the global rheumatology community. Allanore's multifaceted approach—integrating clinical research, genetic studies, cellular biology, and animal model platforms—underlines his comprehensive influence on understanding and treating chronic inflammatory rheumatic diseases.

Legacy and Future Contributions

Yannick Allanore's legacy lies in his pivotal contributions to unraveling the complexities of systemic sclerosis and related conditions. His leadership in research and academia continues to pave the way for innovative therapies and a deeper comprehension of these debilitating diseases. As vice-director of Institut Cochin, his ongoing dedication promises further advancements in the field of rheumatology.

Notable Publications

Phenotyping by persistent inflammation in systemic sclerosis associated interstitial lung disease: a EUSTAR database analysis 2023 (1)

Characteristics of patients with difficult-to-treat rheumatoid arthritis in a French single-centre hospital 2023 (2)

Comparison of subcutaneous and oral methotrexate initiation in rheumatoid arthritis in current practice 2023 (1)

 

 

Aida Sarac Hadzihalilovic | Medicine and Dentistry | Best Researcher Award

Prof Dr. Aida Sarac Hadzihalilovic | Medicine and Dentistry | Best Researcher Award

University of Sarajevo | Bosnia and Herzegovina

Author Profile

Google Scholar

Early Academic Pursuits:

Aida Sarac-Hadzihalilovic commenced her academic journey with her Medical Doctor degree in 1995 from the Medical Faculty, University of Sarajevo. Subsequently, she pursued postgraduate studies in the fundamentals of medical research, culminating in a Master of Science (MSc) degree in 2002. Her dedication led her to earn a Doctoral (PhD) degree in 2006, presenting a thesis on "Quantitative analysis of the hippocampal formation and cognitive dysfunction in posttraumatic stress disorder."

Professional Endeavors:

Starting as an Assistant Lecturer in 1996, she taught anatomy to undergraduates studying medicine, nursing, dentistry, and psychology. Her academic progression led her to positions of increasing responsibility, including Senior Assistant Lecturer (2003-2008), Assistant Professor (2008-2016), and finally, achieving the rank of Full Professor in 2021, all within the Department of Anatomy, Medical Faculty, University of Sarajevo.

Contributions and Research Focus:

Professor Sarac-Hadzihalilovic's vast expertise lies in neuroanatomy and neuroscience, specifically focusing on volumetric brain analysis through structural MRI and the neuropsychological aspects of cognitive dysfunction. She conducted in-depth research on the limbic structures' volumetric analysis, notably the hippocampal formation and amygdala complex, correlating these findings with conditions like post-traumatic stress syndrome and temporal epilepsy. Moreover, her exploration extends to medical anthropology, applying it in skull typisation based on asymmetry, length, width, cephalic index, and cranial capacity, as well as gender skull dimorphism.

Accolades and Recognition:

Her remarkable contributions are evidenced by supervising numerous diploma papers, MSc and PhD students, post-doctoral research fellows, and active involvement in national and international research projects. Professor Sarac-Hadzihalilovic's publication record spans 49 research papers in peer-reviewed international and national journals, 44 contributions to national and international congresses and symposiums, and several authored books, emphasizing the significance of the skull's anatomical-anthropological aspects.

Impact and Influence:

Professor Sarac-Hadzihalilovic's influence transcends academia. She served on scientific committees, advisory boards, editorial boards of peer-reviewed international journals, and held roles as a visiting professor at various universities. Her impact extends to involvement in prestigious EU projects like COST – European Cooperation in Science and Technology, underlining her commitment to advancing research in neuroanatomy and medical anthropology.

Legacy and Future Contributions:

Her legacy lies in shaping the anatomical understanding of future medical professionals. Her continuous commitment to research, publication, and academic engagement promises continued advancements in neuroanatomy, neuroscience, and medical anthropology, enriching medical education and practice for generations to come.

Notable Publications

Radiographic Assessment in the Treatment of Supracondylar Humerus Fractures in Children 2012 (19)

Blood Vessels Distribution in Body and Tail of Pancreas- A Comparative Study of Age Related Variation 2010 (11)

DETERMINATION OF SEX BY DISCRIMINANT FUNCTION ANALYSIS OF LINEAR DIAMETERS IN BOSNIAN HUMAN SKULLS 2017 (4)

Bioanthropological analysis of human occipital condyles using geometric morphometric method 2020 (2)

Analysis of gender differences on pyriform aperture of human skulls using geometric morphometric method 2021 (5)

 

 

Sanita Maleskic Kapo | Medicine and Dentistry | Best Researcher Award

Dr. Sanita Maleskic Kapo | Medicine and Dentistry | Best Researcher Award

University of Sarajevo | Bosnia and Herzegovina

Author Profile

Google Scholar

Early Academic Pursuits

Sanita Maleskic Kapo began her academic journey at the University of Sarajevo, delving into Pharmacology, Clinical Pharmacology, and Toxicology, culminating in her medical doctorate. Her formative years as a general practitioner at the Primary Health Care Center in Bihać enriched her understanding of patient care and community health.

Professional Endeavors

Transitioning into academia, she embraced teaching roles at the Faculty of Medicine, Sarajevo. Starting as a teaching assistant, her dedication and expertise elevated her to the position of Senior Teaching Assistant. Simultaneously, she embarked on a journey towards a Ph.D. in Pharmacology, further deepening her scholarly pursuits. Additionally, her ongoing residency in Clinical Pharmacology amplifies her practical acumen in the field.

Contributions and Research Focus

Sanita's contributions extend across academia and clinical practice. Her research focus in Pharmacology and Clinical Toxicology underscores her commitment to advancing medical knowledge. This commitment is reflected in her concurrent pursuit of a Ph.D. and residency, showcasing a dedication to scholarly and practical excellence.

Accolades and Recognition

Sanita Maleskic Kapo's journey is enriched by her notable accomplishments and dedication, marking her as a standout professional. While specific accolades may not be explicitly outlined, her multifaceted roles and continued academic progression underscore her recognition within the academic and medical spheres.

Impact and Influence

Her impact resonates through her teaching engagements, shaping future medical professionals. Simultaneously, her research endeavors lay the groundwork for advancements in Pharmacology and Clinical Toxicology, potentially influencing medical practices and patient care.

Legacy and Future Contributions

Sanita's legacy lies in her multifaceted contributions to academia, clinical research, and patient care. Her continued pursuit of a Ph.D. and residency promises a future where her expertise will further illuminate the realms of Pharmacology and Clinical Toxicology, potentially leaving an indelible mark in the field.

Notable Publications

Metformin use associated with protective effects for ocular complications in patients with type 2 diabetes - observational study 2017 (27)

Bioanthropological analysis of human occipital condyles using geometric morphometric method 2020 (5)

Analysis of gender differences on pyriform aperture of human skulls using geometric morphometric method 2021 (5)

Effects of topically applied diclofenac and ketoprofen on prostaglandin E2 and Stat3 sera levels and body temperature in two different acute inflammation models in rats 2021 (2)

Evaluation of long-term efficacy of disease-modifying agents in patients with relapsing-remitting multiple sclerosis 2019 (1)