University of Insubria | Italy
Dr. Annalisa Bosi is a distinguished researcher with 909 citations, 29 scientific documents, and an h-index of 15, reflecting her strong impact in the fields of immunology, gastrointestinal pathology, and microbiota–gut–brain axis research. Her early work focused on the phenotypic and functional characterization of innate immune components, particularly NK cells and macrophages, examining their role in tumor pathogenesis and their modulation by chemotherapeutic agents or plant-derived molecules. She later advanced her research to explore molecular and cellular mechanisms underlying major gastrointestinal diseases such as ischemia, intestinal inflammation, and enteric neuropathy, identifying the regulatory role of hyaluronic acid homeostasis in tissue repair. Her recent studies investigate gut microbiota, dysbiosis, and their influence on neurodevelopment and tumor etiopathogenesis, with growing emphasis on prebiotic and probiotic interventions. Dr. Bosi has contributed significantly to understanding experimental models of gut pathology, neuromuscular dysfunction, immunomodulation by virome components, and sex-dependent microbial effects. Her publications span high-impact journals, covering topics such as microbiota–immune interactions, ischemia–reperfusion injury, cytokine–phage crosstalk, and neuroimmune modulation. Through multidisciplinary approaches integrating molecular biology, immunology, and neurogastroenterology, her work continues to shape emerging perspectives on host–microbiota communication and its relevance to disease mechanisms and therapeutic strategies.
Profiles : Scopus | Orcid
Featured Publications
Bosi, A., Baranzini, N., Ponti, A., Moretto, P., Moro, E., Crema, F., Cianci, R., Karousou, E., Viola, M., Passi, A., et al. (2025). Intestinal ischemia/reperfusion injury influences hyaluronan homeostasis in the rat brain. International Journal of Molecular Sciences, 26(20), 10064.
Cianci, R., Caldarelli, M., Brani, P., Bosi, A., Ponti, A., Giaroni, C., & Baj, A. (2025). Cytokines meet phages: A revolutionary pathway to modulating immunity and microbial balance. Biomedicines, 13(5), 1202.
Faggin, S., Cerantola, S., Caputi, V., Tietto, A., Stocco, E., Bosi, A., Ponti, A., Bertazzo, A., Macchi, V., Porzionato, A., et al. (2025). Toll-like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5-hydroxytryptaminergic neurotransmission. British Journal of Pharmacology, 182(8), 1803–1822.
Brani, P., Manzoor, H. Z., Spezia, P. G., Vigezzi, A., Ietto, G., Dalla Gasperina, D., Minosse, C., Bosi, A., Giaroni, C., Carcano, G., et al. (2025). Torque Teno Virus: Lights and shades. Viruses, 17(3), 334.
Dal Lago, S., Brani, P., Ietto, G., Dalla Gasperina, D., Gianfagna, F., Giaroni, C., Bosi, A., Drago Ferrante, F., Genoni, A., Manzoor, H. Z., et al. (2024). Torque Teno Virus: A promising biomarker in kidney transplant recipients. International Journal of Molecular Sciences, 25(14), 7744.
Giambra, V., Pagliari, D., Rio, P., Totti, B., Di Nunzio, C., Bosi, A., Giaroni, C., Gasbarrini, A., Gambassi, G., & Cianci, R. (2023). Gut microbiota, inflammatory bowel disease, and cancer: The role of guardians of innate immunity. Cells, 12(22), 2654.
Bosi, A., Banfi, D., Bistoletti, M., Catizzone, L. M., Chiaravalli, A. M., Moretto, P., Moro, E., Karousou, E., Viola, M., Giron, M. C., et al. (2022). Hyaluronan regulates neuronal and immune function in the rat small intestine and colonic microbiota after ischemic/reperfusion injury. Cells, 11(21), 3370.
Bosi, A., Banfi, D., Bistoletti, M., Moretto, P., Moro, E., Crema, F., Maggi, F., Karousou, E., Viola, M., Passi, A., et al. (2021). Hyaluronan: A neuroimmune modulator in the microbiota–gut axis. Cells, 11(1), 126.
Cerantola, S., Caputi, V., Contarini, G., Mereu, M., Bertazzo, A., Bosi, A., Banfi, D., Mantini, D., Giaroni, C., & Giron, M. C. (2021). Dopamine transporter genetic reduction induces morpho-functional changes in the enteric nervous system. Biomedicines, 9(5), 465.
Banfi, D., Moro, E., Bosi, A., Bistoletti, M., Cerantola, S., Crema, F., Maggi, F., Giron, M. C., Giaroni, C., & Baj, A. (2021). Impact of microbial metabolites on microbiota–gut–brain axis in inflammatory bowel disease. International Journal of Molecular Sciences, 22(4), 1623.
Baci, D., Bosi, A., Parisi, L., Buono, G., Mortara, L., Ambrosio, G., & Bruno, A. (2020). Innate immunity effector cells as inflammatory drivers of cardiac fibrosis. International Journal of Molecular Sciences, 21(19), 7165.
Baci, D., Bosi, A., Gallazzi, M., Rizzi, M., Noonan, D. M., Poggi, A., Bruno, A., & Mortara, L. (2020). The ovarian cancer tumor immune microenvironment (TIME) as target for therapy: A focus on innate immunity cells as therapeutic effectors. International Journal of Molecular Sciences, 21(9), 3125.
Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020). Tryptophan metabolites along the microbiota–gut–brain axis: An interkingdom communication system influencing the gut in health and disease. International Journal of Tryptophan Research, 13, 1–18.