Judith Röske | Biochemistry, Genetics and Molecular Biology | Women Research Award

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Mrs. Judith Röske | Biochemistry, Genetics and Molecular Biology | Women Research Award

University of Luebeck | Germany

Mrs. Judith Röske is a dedicated researcher with a strong focus on molecular virology, antiviral drug discovery, and protease-targeted therapeutic development, contributing to 13 scientific publications across high-impact journals. Her work explores the binding behavior of small-molecule inhibitors to viral 3C proteases, including SARS-CoV-2, EV-D68, EV-A71, and HAV, as well as host proteases such as cathepsins and calpain-1. With expertise in photometry, nanoDSF, MST, and SPR, she has optimized methods for determining key biochemical parameters such as IC₅₀, Tm, and Kᴅ, enabling the effective screening of lead compounds for broad-spectrum antivirals. Her research further investigates RNA-binding mechanisms in HAV 3C protease, shedding light on dual-targeting strategies that may advance anti-picornaviral drug development. She has contributed to influential studies on SARS-CoV-2 main protease inhibitors, including work on novel warhead chemistries, α-ketoamide derivatives, and diastereomeric optimization, reinforcing her impact in antiviral medicinal chemistry. Additionally, earlier contributions in transplant biology and liver preservation highlight her versatility in biochemical and molecular research. Through rigorous structural, kinetic, and biophysical analyses, her body of work adds valuable insight into protease inhibition and therapeutic innovation, supported by a growing citation record within the scientific community.

Profiles : Scopus | Orcid

Featured Publications

Theodoropoulou, M. A., El Kilani, H., Mantzourani, C., Jochmans, D., Neyts, J., Zhang, K., Röske, J., Kokotou, M. G., Hilgenfeld, R., & Kokotos, G. (2025). Thiazolyl 4-carboxylate ketone as a new warhead for a highly potent SARS-CoV-2 main protease inhibitor. European Journal of Medicinal Chemistry, 25(11), 118436.

Akula, R. K., El Kilani, H., Metzen, A., Röske, J., Zhang, K., Göhl, M., Arisetti, N., Marsh, G. P., Maple, H. J., Cooper, M. S., et al. (2025). Structure-based optimization of pyridone α-ketoamides as inhibitors of the SARS-CoV-2 main protease. Journal of Medicinal Chemistry, 68(1).

Cooper, M. S., Zhang, L., Ibrahim, M., Zhang, K., Sun, X., Röske, J., Göhl, M., Brönstrup, M., Cowell, J. K., Sauerhering, L., et al. (2022). Diastereomeric resolution yields highly potent inhibitor of SARS-CoV-2 main protease. Journal of Medicinal Chemistry.

Bernard, V., Gebauer, N., Dinh, T., Stegemann, J., Feller, A. C., & Merz, H. (2014). Applicability of next-generation sequencing to decalcified formalin-fixed and paraffin-embedded chronic myelomonocytic leukaemia samples. International Journal of Clinical and Experimental Pathology.

Le Minh, K., Berger, A., Eipel, C., Kuhla, A., Minor, T., Stegemann, J., & Vollmar, B. (2011). Uncoupling protein-2 deficient mice are not protected against warm ischemia/reperfusion injury of the liver. Journal of Surgical Research, 167.

Stegemann, J., Hirner, A., Rauen, U., & Minor, T. (2010). Use of a new modified HTK solution for machine preservation of marginal liver grafts. Journal of Surgical Research.

Koetting, M., Stegemann, J., & Minor, T. (2010). Dopamine as additive to cold preservation solution improves postischemic integrity of the liver. Transplant International, 23.

Minor, T., Stegemann, J., Hirner, A., & Koetting, M. (2009). Impaired autophagic clearance after cold preservation of fatty livers correlates with tissue necrosis upon reperfusion and is reversed by hypothermic reconditioning. Liver Transplantation.

Stegemann, J., & Minor, T. (2009). Energy charge restoration, mitochondrial protection and reversal of preservation-induced liver injury by hypothermic oxygenation prior to reperfusion. Cryobiology.

Stegemann, J., Hirner, A., Rauen, U., & Minor, T. (2009). Gaseous oxygen persufflation or oxygenated machine perfusion with Custodiol-N for long-term preservation of ischemic rat livers? Cryobiology.

Le Minh, K., Kuhla, A., Abshagen, K., Minor, T., Stegemann, J., Ibrahim, S., Eipel, C., & Vollmar, B. (2009). Uncoupling protein-2 deficiency provides protection in a murine model of endotoxemic acute liver failure. Critical Care Medicine.

Manekeller, S., Seinsche, A., Stegemann, J., & Hirner, A. (2008). Optimising post-conditioning time of marginal donor livers. Langenbeck's Archives of Surgery.

Manekeller, S., Schuppius, A., Stegemann, J., Hirner, A., & Minor, T. (2007). Role of perfusion medium, oxygen and rheology for endoplasmic reticulum stress-induced cell death after hypothermic machine preservation of the liver. Transplant International.

Giovanni Smaldone | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Dr. Giovanni Smaldone | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

IRCCS Synlab SDN | Italy

Dr. Giovanni Smaldone is a highly accomplished researcher whose work spans molecular biology, structural biochemistry, oncology, immunology, and advanced diagnostic technologies. With 1,037 citations, 83 published works, and an h-index of 18, his contributions reflect both productivity and strong scientific impact. His research integrates structural biology, NMR spectroscopy, molecular interactions, and translational oncology, with a particular emphasis on childhood acute lymphoblastic leukemia (ALL). He has led and contributed to numerous funded research projects, including competitive grants focused on long non-coding RNAs, epigenetic markers, and the KCTD protein family in pediatric leukemia. His studies also extend into protein delivery systems, nanogels, cellular imaging, and biobank development for rare pediatric disorders. Dr. Smaldone’s recent publications highlight advancements in 3D refractive index tomography for leukemia cell analysis, targeted drug-delivery platforms, diagnostic biomarkers such as circular RNAs and LINC00958, and the structural mechanisms underlying KCTD–Cullin 3 interactions. His work frequently appears in high-impact journals across molecular sciences, biomedical engineering, nanotechnology, and clinical research. Additionally, he has presented widely at national and international scientific conferences, contributing to knowledge dissemination in cellular biophysics, protein structure, pediatric oncology, and advanced molecular diagnostics.

Profiles : Scopus | Orcid

Featured Publications

Bianco, V., Pirone, D., Schiavo, M., Bianco, V., Miccio, L., Memmolo, P., Smaldone, G., Pecoraro, G., Altieri, F., Salvatore, M., et al. (2026). Quantitative mapping of leukemia cells and intracellular lipid droplets using 3D refractive index tomography in flow cytometry. IEEE Journal of Selected Topics in Quantum Electronics.

Pizzella, M., Accardo, A., Mercurio, F. A., Sibillano, T., Gallo, E., Morelli, G., Smaldone, G., Giannini, C., Leone, M., Balasco, N., et al. (2025). Structural and functional characterization of self-assembling fragments identified from the transthyretin amyloid-like structure. Nanoscale.

Leone, I., Costabile, V., Smaldone, G., Franzese, M., Soricelli, A., & D’Agostino, A. (2025). Arthrospira platensis attenuates endothelial inflammation and monocyte activation. International Journal of Molecular Sciences.

Gallo, E., Smaldone, G., Cimmino, L., Braile, M., Orlandella, F. M., Luciano, N., Accardo, A., & Salvatore, G. (2025). Fmoc-FF nanogel-mediated delivery of doxorubicin and curcumin in thyroid cancer cells. Pharmaceutics.

Balasco, N., Esposito, L., Smaldone, G., Salvatore, M., & Vitagliano, L. (2024). A comprehensive analysis of the structural recognition between KCTD proteins and Cullin 3. International Journal of Molecular Sciences.

Bianco, V., Wang, Z., Brancato, V., Coppola, L., Smaldone, G., D’Aiuto, M., Mossetti, G., Maffettone, P. L., Salvatore, M., & Ferraro, P. (2024). Adaptive space-time digital holography for imaging flow cytometry and tissue slide analysis. In Digital Holography and Three-Dimensional Imaging (DH 2024).

Coppola, L., Grimaldi, A. M., Sarnacchiaro, G., Di Fasano, M. S., Smaldone, G., & Salvatore, M. (2024). An overview of Synlab SDN Biobank’s quality control system. Scientific Reports.

De Martino, L., Mirabelli, P., Quaglietta, L., Ferrara, U. P., Picariello, S., De Gennaro, D. V., Aiello, M., Smaldone, G., Aliberti, F., Spennato, P., et al. (2024). Biobank for craniosynostosis and faciocraniosynostosis: A study protocol. Child’s Nervous System.

Bianco, V., Valentino, M., Pirone, D., Miccio, L., Memmolo, P., Brancato, V., Coppola, L., Smaldone, G., D’Aiuto, M., & Mossetti, G. (2024). Classifying breast cancer and fibroadenoma tissue biopsies using fractal biomarkers in Fourier ptychographic microscopy. Computational and Structural Biotechnology Journal.

De Martino, L., Mirabelli, P., Quaglietta, L., Ferrara, U. P., Picariello, S., De Gennaro, D. V., Aiello, M., Smaldone, G., Aliberti, F., Spennato, P., et al. (2024). Correction: Biobank for craniosynostosis and faciocraniosynostosis. Child’s Nervous System.

Gallo, E., Diaferia, C., Smaldone, G., Rosa, E., Pecoraro, G., Morelli, G., & Accardo, A. (2024). Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells. Scientific Reports.

Gallo, E., Diaferia, C., Smaldone, G., Rosa, E., Pecoraro, G., Morelli, G., & Accardo, A. (2024). Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells. Research Square.

Filomena, A., Smaldone, G., Ginevra, S., Santiago, N., Di Fasano, M. S., Peppino, M., Alessandra, C., Antonia, D. M., Giuliana, B., Rosanna, P., et al. (2024). Identification of a circular RNA isoform of WASHC2A as a prognostic factor for high-risk pediatric B-ALL. Biomedicine & Pharmacotherapy.

Raymundo, J. R., Zhang, H., Smaldone, G., Zhu, W., Daly, K. E., Glennon, B. J., Pecoraro, G., Salvatore, M., Devine, W. A., Lo, C. W., et al. (2024). KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions. Journal of Clinical Investigation.

Altieri, F., Buono, L., Lanzilli, M., Mirabelli, P., Cianflone, A., Beneduce, G., De Matteo, A., Parasole, R., Salvatore, M., & Smaldone, G. (2024). LINC00958 as a diagnostic and prognostic biomarker of childhood B-cell acute lymphoblastic leukemia. Frontiers in Oncology.

Nehal Rami | Agricultural and Biological Sciences | Best Researcher Award

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Dr. Nehal Rami | Agricultural and Biological Sciences | Best Researcher Award

Ganpat University | India

Author Profile

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🎓 Early Academic Pursuits

Dr. Nehal Rami embarked on his academic journey with a strong foundation in the life sciences. He earned his Bachelor's degree in Biotechnology, followed by a Master's in Bioinformatics, and culminated his scholarly path with a Ph.D. in Biotechnology. His educational background reflects a harmonious blend of biological insight and computational skill, empowering him to explore diverse domains such as genomics, structural biology, and molecular informatics.

👨‍🏫 Professional Endeavors

With over 17 years of academic experience, Dr. Rami has been a pillar of education and research at the Mehsana Urban Institute of Sciences, Ganpat University, serving as an Assistant Professor and Coordinator of the Microbiology Department. His role involves teaching, mentoring, curriculum development, and driving student engagement through innovative research projects.

🔬 Contributions and Research Focus

Dr. Rami's research contributions span a wide array of impactful areas. His projects include the creation of bioinformatics tools such as a DNA-to-protein conversion tool and IndiMicroExplorer, a database of Indian microbes. These initiatives showcase his passion for developing practical bioinformatics resources using tools like Perl, ASP, HTML, and Flash. He has extensively published review and research articles on topics like homology modeling, microarray technology, anticancer potential of medicinal plants, and biodegradable plastics from agricultural waste. His work on Annona squamosa L. for breast cancer and Trametes versicolor for health applications reflects his deep commitment to translational and sustainable biosciences.

🏆 Accolades and Recognition

Dr. Rami's research excellence has earned him numerous accolades:

➤ Secured 1st rank in an oral paper presentation on microarray technology at a national e-conference in 2020
➤ Mentored student teams that won Second and Third place in Shodh-GUNI Student Research Conventions in 2020 and 2018
➤ Published multiple Scopus-indexed articles and a book chapter on sustainable agriculture
➤ Guided more than 95 postgraduate students in biological sciences for their dissertations

These achievements underscore his dedication not only to research but also to student empowerment and academic mentorship.

🌍 Impact and Influence

Dr. Rami has left a lasting imprint on the biotechnology and bioinformatics landscape in Gujarat and beyond. His efforts in database development, natural product research, agro-biotechnology, and cancer biology have contributed significantly to the knowledge ecosystem. His interdisciplinary approach has bridged the gap between life sciences and computational biology, enabling practical applications in agriculture, health, and environmental sustainability.

🔮 Legacy and Future Contributions

Looking ahead, Dr. Nehal Rami is poised to further his research impact through major funded projects and innovative teaching methodologies. His recent submission of a ₹5 lakh Major Research Project to KCG exemplifies his ongoing commitment to advancing science and education. With a visionary approach to biotechnology and bioinformatics, Dr. Rami continues to inspire the next generation of researchers and educators.

Publications

📄Potential of Aegle marmelos (L.) Corrêa Extracts in the Management of Breast Cancer: Phytochemical Profiling and Molecular Docking Studies

  • Authors: Nehal Rami, Keyur Bhatt

  • Journal: Pharmacological Research - Natural Products

  • Year: 2025

📄Phytochemical Analysis and In Silico Pharmacological Profiling of Methanolic Extract from Annona squamosa L. Seeds for Breast Cancer

  • Authors: Nehal Rami, Bhushan Kulkarni, Sandesh Chibber

  • Journal: Educational Administration Theory and Practice Journal

  • Year: 2024

📄In vitro Antioxidant and Anticancer Potential of Annona squamosa L. Extracts Against Breast Cancer

  • Authors: Nehal Rami, Bhushan Kulkarni, Sandesh Chibber, Krupali Trivedi, Devendrasinh Jhala, Nilam Parmar

  • Journal: International Journal of Experimental Research and Review

  • Year: 2023

 

Annamaria Russo | Biochemistry, Genetics and Molecular Biology | Excellence in Research Award

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Dr. Annamaria Russo | Biochemistry, Genetics and Molecular Biology | Excellence in Research Award

University of Messina | Italy

Author Profile

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🎓 Early Academic Pursuits

Dr. Annamaria Russo embarked on her scientific journey with a degree in Biological Sciences from the University of Messina in 1997, graduating with top honors (110/110). Her experimental thesis on the functional properties of dolphin hemoglobin marked the beginning of a lifelong interest in comparative and clinical biochemistry. She earned her Professional Biologist Certification and later pursued a Ph.D. in Cellular Biology and Biotechnology in 2014, exploring the metabolic mechanisms and functionality of red blood cells through exogenous molecules.

👩‍🔬 Professional Endeavors

Dr. Russo's career has interwoven research, teaching, and academic mentorship. She began as a research fellow at the Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences (Chibiofaram), focusing on the structural and functional analysis of respiratory proteins in marine organisms. She also held postgraduate research positions in international institutions, including a notable stay at the Institute of Physiology at the Academy of Sciences in Prague. Parallel to her research, she has been a tenured mathematics and science teacher in several secondary schools in Sicily. Since 2006, she has held the title of “Cultore della Materia” in Biochemistry, consistently participating in exam boards and teaching activities.

🧪 Contributions and Research Focus

Dr. Russo's research focuses on biochemistry, erythrocyte metabolism, oxidative stress, protein-ligand interactions, and the thermodynamic characterization of blood components. She has extensively studied the Band 3 protein, hemoglobin functionalities, and interactions in both human and marine organisms. Her studies span from environmental biochemistry to medical applications, including research on red blood cells in diseases like ALS, sickle cell anemia, and the biochemical impact of COVID-19. Her research also explores natural antioxidant compounds and their role in protecting red blood cells, such as polyphenols and caffeine. Additionally, she has contributed to the development of bioplastics and biosensors for environmental applications.

🏅 Accolades and Recognition

With 43 scientific publications, 757 citations, and an H-index of 17, Dr. Russo has established herself as a respected voice in her field. She has served as an editorial board member for high-impact journals such as Stresses and Biology and has been a guest editor for thematic issues in journals like Antioxidants and IJMS (International Journal of Molecular Sciences). She also regularly reviews articles for prominent journals including Molecules and The Journal of Neuroscience Research.

Her research collaborations include prestigious institutions such as:

  • CNR (Rome, Milan, Messina)

  • Catholic University of the Sacred Heart

  • University of Palermo

  • University of Enna “Kore”

  • ARPACAL Calabria

  • University of Cassino

🌍 Impact and Influence

Dr. Russo has mentored numerous undergraduate and graduate students in laboratory settings and thesis projects, shaping the next generation of biochemists. Her work on erythrocyte metabolism and natural antioxidants has implications for clinical diagnostics, environmental monitoring, and neurodegenerative disease prevention. Her multidisciplinary collaborations have allowed her to bridge fundamental science with practical applications.

🔮 Legacy and Future Contributions

With ongoing research in the biochemical implications of environmental stressors, cell metabolism, and sustainable material development, Dr. Russo remains at the forefront of scientific innovation. Her latest conference presentations in 2025 on bioplastic sensors and biochemical characterization of metastasis underscore her commitment to translational research that benefits both health and the environment. Her legacy is that of a passionate scientist and educator dedicated to advancing knowledge in biochemistry while mentoring future scholars and contributing meaningfully to both academic and applied scientific communities.

Publications

📄 Epicatechin Influence on Biochemical Modification of Human Erythrocyte Metabolism and Membrane Integrity
Authors: Russo, Annamaria; Patanè, Giuseppe Tancredi; Laganá, Giuseppina; Tellone, Ester; Putaggio, Stefano
Journal: International Journal of Molecular Sciences
Year: 2024

📄 Crosstalk Between Sickle Cell Disease and Ferroptosis
Authors: Russo, Annamaria; Patanè, Giuseppe Tancredi; Calderaro, Antonella; Tellone, Ester; Putaggio, Stefano
Journal: International Journal of Molecular Sciences
Year: 2025

📄 Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols
Authors: Russo, Annamaria; Putaggio, Stefano; Tellone, Ester; Barreca, Davide; Patanè, Giuseppe Tancredi
Journal: Molecules
Year: 2025

📄 Canine and Human Red Blood Cells: Biochemical Mechanisms for the Control of Heat Dissipation
Authors: Russo, Annamaria; Patanè, Giuseppe Tancredi; Putaggio, Stefano; Barreca, Davide; Laganà, Giuseppina
Journal: Stresses
Year: 2024