Prof. John Matsoukas | Chemistry | Excellence in Innovation Award
University of Patras | Greece
Professor John Matsoukas is a distinguished scholar in the field of chemistry and drug discovery, with over four decades of academic and research contributions spanning peptide chemistry, medicinal chemistry, and rational drug design. He has served as Professor of Chemistry at the University of Patras since 1995 and has held multiple visiting and adjunct appointments internationally, reflecting his global academic influence. His pioneering work in the design of non-peptide mimetics for peptide hormones and immune-related targets has significantly advanced research in hypertension, cancer, multiple sclerosis, and antiviral therapeutics. A prolific author, he has published 189 peer-reviewed papers, 50 book chapters, and numerous conference proceedings, bringing his total scholarly outputs to more than 600. His research has been widely recognized, accumulating over 5,500 citations and an h-index of 42, underscoring both productivity and impact within the scientific community. In addition, his innovative contributions are reflected in multiple patents, editorial roles, and his leadership in founding the Graduate Program in Medicinal Chemistry: Drug Discovery and Design, the first Euromaster-awarded program in Greece. Beyond academia, he has also established spin-offs and startups, securing over €15 million in grants, and continues to shape international biomedical networks, cementing his legacy as a leading figure in drug discovery and medicinal chemistry.
Featured Publications
"Docking Simulations of G-Protein Coupled Receptors Uncover Crossover Binding Patterns of Diverse Ligands to Angiotensin, Alpha-Adrenergic and Opioid Receptors: Implications for Cardiovascular Disease and Addiction"
"Gating Mechanism for Biased Agonism at Angiotensin II Type 1 Receptors"
"Semi-Supervised Learning for Predicting Multiple Sclerosis"
"Computational Evidence for Bisartan Arginine Blockers as Next-Generation Pan-Antiviral Therapeutics Targeting SARS-CoV-2, Influenza, and Respiratory Syncytial Viruses"
"A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose"
"Density functional theory and enzyme studies support interactions between angiotensin receptor blockers and angiotensin converting enzyme-2: Relevance to coronavirus 2019"
"Myelin Oligodendrocyte Glycoprotein (MOG)35–55 Mannan Conjugate Induces Human T-Cell Tolerance and Can Be Used as a Personalized Therapy for Multiple Sclerosis"
"Structural Features Influencing the Bioactive Conformation of Angiotensin II and Angiotensin A: Relationship between Receptor Desensitization, Addiction, and the Blood–Brain Barrier"