MInjie Wang | Pharmacology, Toxicology and Pharmaceutical Science | Research Excellence Award

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Prof. Minjie Wang | Pharmacology, Toxicology and Pharmaceutical Science | Research Excellence Award

Inner Mongolia Medical University | China

Prof. Minjie Wang is an accomplished biomedical researcher with a strong scholarly record, reflected by an h-index of 6, 15 peer-reviewed documents, and 93 citations. His research focuses on the discovery and functional characterization of active substances from Traditional Chinese Medicine and Mongolian Medicine, with particular emphasis on the pathological mechanisms of cardiovascular and cerebrovascular diseases and the identification of therapeutic drug targets. A major theme of his work is the role of AMP-activated protein kinase (AMPK) in vascular inflammation, endothelial dysfunction, atherosclerosis, metabolic syndrome, and adipose tissue remodeling. His studies integrate advanced in vivo animal models—including atherosclerosis, myocardial ischemia-reperfusion injury, arrhythmia, and cerebral ischemia—with comprehensive in vitro approaches encompassing cell culture, molecular biology, immunohistochemistry, and biochemical analysis. Prof. Wang has published extensively in high-impact journals such as European Heart Journal, Cell Death & Disease, Frontiers in Microbiology, Acta Pharmacologica Sinica, and European Journal of Pharmacology, contributing significant insights into vascular biology, inflammation, metabolism, and translational pharmacology. His work also includes patented innovations related to AMPK activators for vascular inflammation and endothelial protection, underscoring both scientific depth and translational relevance.

 

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Featured Publications

 

Yucheng Lu | Neuroscience | Research Excellence Award

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Prof. Yucheng Lu | Neuroscience | Research Excellence Award

Linyi People's Hospital | China

Prof. Yucheng Lu is a distinguished researcher whose scholarly contributions span cancer biology, immunology, and translational biomedical sciences. With 352 citations, 26 indexed publications, and an h-index of 13, he has established a strong research footprint in molecular oncology and disease pathology. Over his academic career, he has published 40 peer-reviewed papers, including 25 as first or corresponding author, reflecting consistent leadership in scientific inquiry. His work encompasses cutting-edge topics such as tumor-associated macrophage regulation in glioma, prognostic biomarkers in low-grade glioma, colorectal cancer therapeutics, and single-cell transcriptomics in esophageal cancer. In addition, he has explored metabolic and immunological disease interactions, cancer proliferation mechanisms, and neural electrophysiological responses. As a principal investigator, he has led 7 provincial and municipal research projects and contributed to 8 national and ministerial-level initiatives, demonstrating strong project management and interdisciplinary collaboration. His research excellence has earned 3 Science and Technology Achievement Awards, alongside innovations represented by 1 invention patent and 6 software copyrights. Through these achievements, Prof. Lu continues to advance biomedical research with significant scientific, clinical, and technological impact.

Profile : Scopus | Orcid

Featured Publications

Shi, H., Cheng, Y., Chao, D., Song, Q., Han, L., Li, H., Lu, Y., & Wang, M. (2025). Spatiotemporal profiling of endocytic regulators in the immunosuppressive TAM microenvironment of glioma. Brain Research, 150086. (In press)

Author names not provided. (2025). Identification of CDKN3 overexpression as a marker of poor prognosis and potential therapeutic target in low-grade glioma. Scientific Reports.

Author names not provided. (2025). Okanin suppresses the growth of colorectal cancer cells by targeting Peroxiredoxin 5. Advanced Science.

Shi, K., Li, Y., Yang, L., Zhang, Z., Guo, D., Zhang, J., & Lu, Y. (2022). Profiling transcriptional heterogeneity of epithelium, fibroblasts, and immune cells in esophageal squamous cell carcinoma by single-cell RNA sequencing. The FASEB Journal, 0892-6638.

Zhao, J. Z., Lu, Y. C., Wang, Y. M., Xiao, B. L., Li, H. Y., Lee, S. C., & Wang, L. J. (2022). Association between diabetes and acute lymphocytic leukemia, acute myeloid leukemia, non-Hodgkin lymphoma, and multiple myeloma. International Journal of Diabetes in Developing Countries, 0973-3930.

Shi, K., Zhang, J. Z., Yang, L., Li, N. N., Yue, Y., Du, X. H., Zhang, X. Z., Lu, Y. C., & Guo, D. (2021). Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma. BMC Cancer, 1471-2407.

Lu, Y., Lv, B., & Song, Q. (2019). Transcranial electrical stimulation motor-evoked potentials in a spinal cord ischaemia rabbit model. Chinese Neurosurgical Journal, 2057-4967.

Lu, Y. C., Wang, P., Wang, J., Ma, R., & Lee, S. C. (2019). PCNA and JNK1-Stat3 pathways respectively promote and inhibit diabetes-associated centrosome amplification by targeting the ROCK1/14-3-3σ complex in human colon cancer HCT116 cells. Journal of Cellular Physiology.

Zhuowei Luo | Pharmacology, Toxicology and Pharmaceutical Science | Research Excellence Award

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Mr. Zhuowei Luo | Pharmacology, Toxicology and Pharmaceutical Science | Research Excellence Award

Hubei University of Chinese Medicine | China

Mr. Zhuowei Luo is an emerging researcher recognized for effectively integrating classical Traditional Chinese Medicine (TCM) theory with modern biomedical science, demonstrating strong expertise in molecular mechanism analysis and advanced metabolomics for chronic disease research. His notable scientific contribution is a co-authored publication in the Journal of Ethnopharmacology (Q2, IF 5.14), where he helped elucidate how Allium macrostemon delays chronic renal failure by modulating the IL-17 signaling pathway and altering tryptophan and glycerophospholipid metabolism. This work represents the first comprehensive study connecting immunological regulation with multi-omics profiling to explain the therapeutic mechanisms of this TCM herb, providing a meaningful model for modernizing traditional medicine through systems biology. His role in the project included designing and validating qPCR primers, conducting network pharmacology to identify key molecular targets, performing metabolomics and transcriptomics data analyses, and carrying out histopathological assessments. Through these contributions, he demonstrated an advanced ability to apply interdisciplinary approaches—combining immunology, pharmacology, and bioinformatics—to uncover mechanistic insights into natural product–based interventions. His research reflects scientific maturity beyond typical early-stage experience and contributes to the growing evidence supporting data-driven modernization of TCM in chronic disease treatment.

Profile : Orcid

Featured Publication

Zhao, Y., Ge, J. X., Zhang, N., Lei, Z. X., Sun, S. Y., Luo, Z. W., Yang, Y. F., & Wu, H. Z. (2025). Allium macrostemon Bge. delays chronic renal failure by modulating IL-17 signaling pathway and affecting tryptophan/glycerophospholipid metabolism. Journal of Ethnopharmacology, 120946.

Annalisa Bosi | Pharmacology, Toxicology and Pharmaceutical Science | Best Researcher Award

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Dr. Annalisa Bosi | Pharmacology, Toxicology and Pharmaceutical Science | Best Researcher Award

University of Insubria | Italy

Dr. Annalisa Bosi is a distinguished researcher with 909 citations, 29 scientific documents, and an h-index of 15, reflecting her strong impact in the fields of immunology, gastrointestinal pathology, and microbiota–gut–brain axis research. Her early work focused on the phenotypic and functional characterization of innate immune components, particularly NK cells and macrophages, examining their role in tumor pathogenesis and their modulation by chemotherapeutic agents or plant-derived molecules. She later advanced her research to explore molecular and cellular mechanisms underlying major gastrointestinal diseases such as ischemia, intestinal inflammation, and enteric neuropathy, identifying the regulatory role of hyaluronic acid homeostasis in tissue repair. Her recent studies investigate gut microbiota, dysbiosis, and their influence on neurodevelopment and tumor etiopathogenesis, with growing emphasis on prebiotic and probiotic interventions. Dr. Bosi has contributed significantly to understanding experimental models of gut pathology, neuromuscular dysfunction, immunomodulation by virome components, and sex-dependent microbial effects. Her publications span high-impact journals, covering topics such as microbiota–immune interactions, ischemia–reperfusion injury, cytokine–phage crosstalk, and neuroimmune modulation. Through multidisciplinary approaches integrating molecular biology, immunology, and neurogastroenterology, her work continues to shape emerging perspectives on host–microbiota communication and its relevance to disease mechanisms and therapeutic strategies.

Profiles : Scopus | Orcid

Featured Publications

Bosi, A., Baranzini, N., Ponti, A., Moretto, P., Moro, E., Crema, F., Cianci, R., Karousou, E., Viola, M., Passi, A., et al. (2025). Intestinal ischemia/reperfusion injury influences hyaluronan homeostasis in the rat brain. International Journal of Molecular Sciences, 26(20), 10064.

Cianci, R., Caldarelli, M., Brani, P., Bosi, A., Ponti, A., Giaroni, C., & Baj, A. (2025). Cytokines meet phages: A revolutionary pathway to modulating immunity and microbial balance. Biomedicines, 13(5), 1202.

Faggin, S., Cerantola, S., Caputi, V., Tietto, A., Stocco, E., Bosi, A., Ponti, A., Bertazzo, A., Macchi, V., Porzionato, A., et al. (2025). Toll-like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5-hydroxytryptaminergic neurotransmission. British Journal of Pharmacology, 182(8), 1803–1822.

Brani, P., Manzoor, H. Z., Spezia, P. G., Vigezzi, A., Ietto, G., Dalla Gasperina, D., Minosse, C., Bosi, A., Giaroni, C., Carcano, G., et al. (2025). Torque Teno Virus: Lights and shades. Viruses, 17(3), 334.

Dal Lago, S., Brani, P., Ietto, G., Dalla Gasperina, D., Gianfagna, F., Giaroni, C., Bosi, A., Drago Ferrante, F., Genoni, A., Manzoor, H. Z., et al. (2024). Torque Teno Virus: A promising biomarker in kidney transplant recipients. International Journal of Molecular Sciences, 25(14), 7744.

Giambra, V., Pagliari, D., Rio, P., Totti, B., Di Nunzio, C., Bosi, A., Giaroni, C., Gasbarrini, A., Gambassi, G., & Cianci, R. (2023). Gut microbiota, inflammatory bowel disease, and cancer: The role of guardians of innate immunity. Cells, 12(22), 2654.

Bosi, A., Banfi, D., Bistoletti, M., Catizzone, L. M., Chiaravalli, A. M., Moretto, P., Moro, E., Karousou, E., Viola, M., Giron, M. C., et al. (2022). Hyaluronan regulates neuronal and immune function in the rat small intestine and colonic microbiota after ischemic/reperfusion injury. Cells, 11(21), 3370.

Bosi, A., Banfi, D., Bistoletti, M., Moretto, P., Moro, E., Crema, F., Maggi, F., Karousou, E., Viola, M., Passi, A., et al. (2021). Hyaluronan: A neuroimmune modulator in the microbiota–gut axis. Cells, 11(1), 126.

Cerantola, S., Caputi, V., Contarini, G., Mereu, M., Bertazzo, A., Bosi, A., Banfi, D., Mantini, D., Giaroni, C., & Giron, M. C. (2021). Dopamine transporter genetic reduction induces morpho-functional changes in the enteric nervous system. Biomedicines, 9(5), 465.

Banfi, D., Moro, E., Bosi, A., Bistoletti, M., Cerantola, S., Crema, F., Maggi, F., Giron, M. C., Giaroni, C., & Baj, A. (2021). Impact of microbial metabolites on microbiota–gut–brain axis in inflammatory bowel disease. International Journal of Molecular Sciences, 22(4), 1623.

Baci, D., Bosi, A., Parisi, L., Buono, G., Mortara, L., Ambrosio, G., & Bruno, A. (2020). Innate immunity effector cells as inflammatory drivers of cardiac fibrosis. International Journal of Molecular Sciences, 21(19), 7165.

Baci, D., Bosi, A., Gallazzi, M., Rizzi, M., Noonan, D. M., Poggi, A., Bruno, A., & Mortara, L. (2020). The ovarian cancer tumor immune microenvironment (TIME) as target for therapy: A focus on innate immunity cells as therapeutic effectors. International Journal of Molecular Sciences, 21(9), 3125.

Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020). Tryptophan metabolites along the microbiota–gut–brain axis: An interkingdom communication system influencing the gut in health and disease. International Journal of Tryptophan Research, 13, 1–18.

Giovanni Smaldone | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Dr. Giovanni Smaldone | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

IRCCS Synlab SDN | Italy

Dr. Giovanni Smaldone is a highly accomplished researcher whose work spans molecular biology, structural biochemistry, oncology, immunology, and advanced diagnostic technologies. With 1,037 citations, 83 published works, and an h-index of 18, his contributions reflect both productivity and strong scientific impact. His research integrates structural biology, NMR spectroscopy, molecular interactions, and translational oncology, with a particular emphasis on childhood acute lymphoblastic leukemia (ALL). He has led and contributed to numerous funded research projects, including competitive grants focused on long non-coding RNAs, epigenetic markers, and the KCTD protein family in pediatric leukemia. His studies also extend into protein delivery systems, nanogels, cellular imaging, and biobank development for rare pediatric disorders. Dr. Smaldone’s recent publications highlight advancements in 3D refractive index tomography for leukemia cell analysis, targeted drug-delivery platforms, diagnostic biomarkers such as circular RNAs and LINC00958, and the structural mechanisms underlying KCTD–Cullin 3 interactions. His work frequently appears in high-impact journals across molecular sciences, biomedical engineering, nanotechnology, and clinical research. Additionally, he has presented widely at national and international scientific conferences, contributing to knowledge dissemination in cellular biophysics, protein structure, pediatric oncology, and advanced molecular diagnostics.

Profiles : Scopus | Orcid

Featured Publications

Bianco, V., Pirone, D., Schiavo, M., Bianco, V., Miccio, L., Memmolo, P., Smaldone, G., Pecoraro, G., Altieri, F., Salvatore, M., et al. (2026). Quantitative mapping of leukemia cells and intracellular lipid droplets using 3D refractive index tomography in flow cytometry. IEEE Journal of Selected Topics in Quantum Electronics.

Pizzella, M., Accardo, A., Mercurio, F. A., Sibillano, T., Gallo, E., Morelli, G., Smaldone, G., Giannini, C., Leone, M., Balasco, N., et al. (2025). Structural and functional characterization of self-assembling fragments identified from the transthyretin amyloid-like structure. Nanoscale.

Leone, I., Costabile, V., Smaldone, G., Franzese, M., Soricelli, A., & D’Agostino, A. (2025). Arthrospira platensis attenuates endothelial inflammation and monocyte activation. International Journal of Molecular Sciences.

Gallo, E., Smaldone, G., Cimmino, L., Braile, M., Orlandella, F. M., Luciano, N., Accardo, A., & Salvatore, G. (2025). Fmoc-FF nanogel-mediated delivery of doxorubicin and curcumin in thyroid cancer cells. Pharmaceutics.

Balasco, N., Esposito, L., Smaldone, G., Salvatore, M., & Vitagliano, L. (2024). A comprehensive analysis of the structural recognition between KCTD proteins and Cullin 3. International Journal of Molecular Sciences.

Bianco, V., Wang, Z., Brancato, V., Coppola, L., Smaldone, G., D’Aiuto, M., Mossetti, G., Maffettone, P. L., Salvatore, M., & Ferraro, P. (2024). Adaptive space-time digital holography for imaging flow cytometry and tissue slide analysis. In Digital Holography and Three-Dimensional Imaging (DH 2024).

Coppola, L., Grimaldi, A. M., Sarnacchiaro, G., Di Fasano, M. S., Smaldone, G., & Salvatore, M. (2024). An overview of Synlab SDN Biobank’s quality control system. Scientific Reports.

De Martino, L., Mirabelli, P., Quaglietta, L., Ferrara, U. P., Picariello, S., De Gennaro, D. V., Aiello, M., Smaldone, G., Aliberti, F., Spennato, P., et al. (2024). Biobank for craniosynostosis and faciocraniosynostosis: A study protocol. Child’s Nervous System.

Bianco, V., Valentino, M., Pirone, D., Miccio, L., Memmolo, P., Brancato, V., Coppola, L., Smaldone, G., D’Aiuto, M., & Mossetti, G. (2024). Classifying breast cancer and fibroadenoma tissue biopsies using fractal biomarkers in Fourier ptychographic microscopy. Computational and Structural Biotechnology Journal.

De Martino, L., Mirabelli, P., Quaglietta, L., Ferrara, U. P., Picariello, S., De Gennaro, D. V., Aiello, M., Smaldone, G., Aliberti, F., Spennato, P., et al. (2024). Correction: Biobank for craniosynostosis and faciocraniosynostosis. Child’s Nervous System.

Gallo, E., Diaferia, C., Smaldone, G., Rosa, E., Pecoraro, G., Morelli, G., & Accardo, A. (2024). Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells. Scientific Reports.

Gallo, E., Diaferia, C., Smaldone, G., Rosa, E., Pecoraro, G., Morelli, G., & Accardo, A. (2024). Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells. Research Square.

Filomena, A., Smaldone, G., Ginevra, S., Santiago, N., Di Fasano, M. S., Peppino, M., Alessandra, C., Antonia, D. M., Giuliana, B., Rosanna, P., et al. (2024). Identification of a circular RNA isoform of WASHC2A as a prognostic factor for high-risk pediatric B-ALL. Biomedicine & Pharmacotherapy.

Raymundo, J. R., Zhang, H., Smaldone, G., Zhu, W., Daly, K. E., Glennon, B. J., Pecoraro, G., Salvatore, M., Devine, W. A., Lo, C. W., et al. (2024). KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions. Journal of Clinical Investigation.

Altieri, F., Buono, L., Lanzilli, M., Mirabelli, P., Cianflone, A., Beneduce, G., De Matteo, A., Parasole, R., Salvatore, M., & Smaldone, G. (2024). LINC00958 as a diagnostic and prognostic biomarker of childhood B-cell acute lymphoblastic leukemia. Frontiers in Oncology.

Valentina Mihaylova | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Mrs. Valentina Mihaylova | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

Medical University-Plovdiv | Bulgaria

Mrs. Valentina Mihaylova is a dedicated researcher and specialist in medical chemistry with a strong focus on cellular metabolism, mitochondrial function, oxidative stress, and autoimmune diseases. With an h-index of 2, she has authored five scientific publications, which have collectively garnered 14 citations, reflecting her growing impact in medical biology and clinical research. Her work encompasses the study of markers of oxidative stress and insulin resistance in chronic autoimmune Hashimoto’s thyroiditis, cellular metabolic profiling in children with autism spectrum disorders, and the evaluation of therapeutic effects in rheumatoid arthritis through mitochondrial function and bioenergetic metabolism. Mrs. Mihaylova’s research also explores intestinal permeability, systemic inflammation, and the pharmacological effects of treatments such as methotrexate and JAK inhibitors on mitochondrial function and oxidative stress. She has actively contributed to numerous national and international conferences, presenting pioneering findings on the role of mitochondria, autophagy, and inflammation in autoimmune and rheumatologic conditions. Her academic and professional trajectory, spanning positions from clinical chemist to Master of Medical Chemistry at the Medical University of Plovdiv, is marked by a commitment to advancing knowledge in medical biology and translational research. Through her multidisciplinary approach, Mrs. Mihaylova continues to elucidate complex biochemical mechanisms underlying disease pathology and therapeutic responses, establishing herself as an emerging contributor to the field of medical and clinical biochemistry.

Profiles : Scopus | Orcid

Featured Publications

Mihaylova, V., Tomov, D., Karalilova, R., Batalov, Z., Batalov, A., Sarafian, V., & Kazakova, M. (2025). Effects of methotrexate and tofacitinib on mitochondrial function and oxidative stress in human synovial cells in vitro. International Journal of Molecular Sciences, 26(17), 8173.

Tomov, D. G., Levterova, B. A., Mihaylova, V. N., Troev, D. M., Miteva, M. Z., Uzunova, Y. I., & Orbetzova, M. M. (2024). Influence of the increase in intestinal permeability and microbiota change in the development of Hashimoto's thyroiditis: A systematic review. Endocrine and Metabolic Science, 100195.

Mihaylova, V., Kazakova, M., Batalov, Z., Karalilova, R., Batalov, A., & Sarafian, V. (2023). JAK inhibitors improve ATP production and mitochondrial function in rheumatoid arthritis: A pilot study. Rheumatology International.

Panpan Hou | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Assist. Prof. Dr. Panpan Hou | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

Macau University Of Science And Technology | Macau

Assist. Prof. Dr. Panpan Hou is a distinguished researcher in the field of Biomedical Engineering and Biophysics, with a prolific record of 375 documents, 541 citations, and an h-index of 16. After obtaining a B.S. in Biomedical Engineering and a Ph.D. in Biophysics from Huazhong University of Science and Technology, Dr. Hou completed postdoctoral training at Washington University in St. Louis before joining Macau University of Science and Technology as an Assistant Professor in 2021. Dr. Hou’s research focuses on ion channel physiology, voltage-sensor domain (VSD) mechanisms, and electro-mechanical coupling, elucidating complex molecular processes such as the VSD-pore coupling in KCNQ1 channels and identifying novel modulators with therapeutic potential. He has made significant contributions to drug screening, cardiovascular disease modeling, and electrophysiology, publishing high-impact work in journals including Nature Communications, PNAS, eLife, Circulation Research, and Scientific Reports. Dr. Hou has received multiple awards including the AHA Postdoctoral Fellowship, Best Poster Awards at international symposia, and the 2025 Best Research Output Award from Macau University of Science and Technology. Beyond research, he actively mentors students, serves on editorial boards, and contributes to national and international scientific societies. With a strong track record of innovation, mentorship, and high-impact publications, Dr. Hou exemplifies excellence in biomedical research and is poised to advance the understanding of ion channel physiology and therapeutic interventions.

Profiles : Scopus | Orcid | Google Scholar

Featured Publications

Zhong, L., Lin, X., Cheng, X., Wan, S., Hua, Y., Nan, W., Hu, B., Peng, X., Zhou, Z., Zhang, Q., Yang, H., Noé, F., Yan, Z., Jiang, D., Zhang, H., Liu, F., Xiao, C., Zhou, Z., Mou, Y., Yu, H., Ma, L., Huang, C., Wong, V. K. W., Chung, S. K., Shen, B., Jiang, Z.-H., Neher, E., Zhu, W., Zhang, J., & Hou, P. (2025). Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating. Cell Research.

Hou, P., Zhao, L., Zhong, L., Shi, J., Wang, H. Z., Gao, J., Liu, H., Zuckerman, J., Cohen, I. S., & Cui, J. (2024). The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response. PNAS Nexus.

Liu, Y., Xu, X., Gao, J., Naffaa, M. M., Liang, H., Shi, J., Wang, H. Z., Yang, N.-D., Hou, P., & Zhao, W. (2022). Author correction: A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation. Communications Biology.

Dou, A., Kang, P. W., Hou, P., Zaydman, M. A., Zheng, J., Jegla, T., & Cui, J. (2021). Principles of sensor-effector organization in six-transmembrane ion channels.

Lin, Y., Grinter, S. Z., Lu, Z., Xu, X., Wang, H. Z., Liang, H., Hou, P., Gao, J., Clausen, C., & Shi, J. (2021). Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects. Proceedings of the National Academy of Sciences.

Liu, Y., Xu, X., Gao, J., Naffaa, M. M., Liang, H., Shi, J., Wang, H. Z., Yang, N.-D., Hou, P., & Zhao, W. (2020). A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation. Communications Biology.

Taylor, K. C., Kang, P. W., Hou, P., Yang, N.-D., Kuenze, G., Smith, J. A., Shi, J., Huang, H., McFarland White, K., & Peng, D. (2020). Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. eLife.

Hou, P., Kang, P. W., Kongmeneck, A. D., Yang, N.-D., Liu, Y., Shi, J., Xu, X., McFarland White, K., Zaydman, M. A., Kasimova, M. A., Seebohm, M., Zhong, L., Zou, X., Tarek, M., & Cui, J. (2020). Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation. Nature Communications.

Zhu, W., Mazzanti, A., Voelker, T. L., Hou, P., Moreno, J. D., Angsutararux, P., Naegle, K. M., Priori, S. G., & Silva, J. R. (2019). Predicting patient response to the antiarrhythmic mexiletine based on genetic variation: Personalized medicine for long QT syndrome. Circulation Research.

Hou, P., Kang, P. W., Kongmeneck, A. D., Yang, N.-D., Liu, Y., Shi, J., Xu, X., McFarland White, K., Zaydman, M. A., Kasimova, M. A., Seebohm, M., Zhong, L., Zou, X., Tarek, M., & Cui, J. (2019). Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activation.

Hou, P., Shi, J., McFarland White, K., Gao, Y., & Cui, J. (2019). ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling. eLife.

Hou, P., Shi, J., McFarland White, K., Gao, Y., & Cui, J. (2019). ML277 specifically enhances pore opening of KCNQ1 with VSD at the activated state by modulating VSD-pore coupling.

Hou, P., Eldstrom, J., Shi, J., Zhong, L., McFarland, K., Gao, Y., Fedida, D., & Cui, J. (2017). Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening. Nature Communications.

Abdelaziz Ghanemi | Medicine and Dentistry | Best Researcher Award

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Dr. Abdelaziz Ghanemi | Medicine and Dentistry | Best Researcher Award

Laval University | Canada

Author Profile

Orcid

Google Scholar

🎓 Early Academic Pursuits

Dr. Abdelaziz Ghanemi’s academic foundation reflects both intellectual rigor and global engagement. He graduated as the top student from the pharmacy program at Mentouri University of Constantine in Algeria. His quest for advanced scientific knowledge led him to China Pharmaceutical University, where he earned a Master of Science in Pharmacology, completing more than twice the credit requirement. His research there involved high-throughput screening for dopamine D5 receptor ligands—a project using transgenic cell lines and cutting-edge fluorescence assays. He then pursued a Ph.D. in Molecular Medicine at Laval University in Canada. His doctoral thesis was a comprehensive study of gene regulation in obesity and exercise, particularly focusing on TFF2 and SPARC, and was constructed from an impressive 27 peer-reviewed publications, marking an extraordinary achievement in biomedical research.

🧪 Professional Endeavors

Dr. Ghanemi’s professional journey spans Algeria, China, and Canada, covering a spectrum of scientific, academic, and community roles. His appointments include:

👨‍🔬 Postdoctoral Fellowships at CHU de Québec–Université Laval Research Center and LOEX Regenerative Medicine Lab, where he explored obesity, vascular calcification, and 3D bioprinting for tissue engineering.
👨‍🏫 Visiting Scholar at the University of Victoria (2024), working under Prof. Stephanie Willerth on bioprinting applications in regenerative medicine.
🔬 Research Professional at the CHUQ’s Functional Genomics and SAGE platform, applying gene expression tools to decode metabolic and ageing pathways.
🌍 Interpreter and Science Communicator, fluent in Arabic, English, French, and Chinese, enhancing cross-cultural scientific collaboration.

In addition to these, Dr. Ghanemi has participated in numerous internships, including hospital pharmacy and neurobiology labs, and taught pharmacology in China—demonstrating both practical and pedagogical expertise.

🔬 Contributions and Research Focus

Dr. Ghanemi’s research covers some of the most pressing biomedical themes of our time:

🧠 Obesity and metabolism, focusing on gene-environment interactions and exercise-induced molecular changes
💪 Regenerative medicine, especially the roles of SPARC and TFF2 in ageing, obesity, and tissue repair
🧬 Genomic and transcriptomic analysis using transgenic animal models and advanced sequencing platforms
🩺 Chronic kidney disease and mineral bone disorders, examining vitamin D pathways and Wnt/β-catenin signaling

His scholarly productivity includes over 50 scientific articles, a Google Scholar h-index of 22, and contributions to high-impact journals such as Biomedicines, Metabolites, Biology, Medicines, and Cytokine.

🏅 Accolades and Recognition

Dr. Ghanemi’s excellence has been recognized globally:

🥇 “Best Student Award” during his undergraduate pharmacy studies
🏆 Oral Presentation Award at ICOMES & AOCO 2019 in Seoul for research on SPARC and exercise
🎓 Vanier Canada Graduate Scholarship Nominee, one of Canada’s most prestigious honors
💬 “Student Seminar Award” by CHU de Québec Research Center for outstanding research communication
🏅 “I Stand With Her” Award at the Women in Medicine Summit (Chicago), honoring his advocacy for women's health
🌍 Laval University Representative at the Canadian Student Health Research Forum (2021)

These distinctions underscore both the scientific value and societal impact of his work.

🌐 Impact and Influence

Dr. Ghanemi’s influence extends beyond the laboratory. His work on exercise mimetics, bioenergetics, and gene-environment crosstalk holds implications for public health, geriatrics, and personalized medicine. As an editor for a special issue in Biomedicines (2024–2025), he is shaping academic dialogue on metabolism and tissue engineering. His editorial contributions and published opinions have influenced how we view obesity, exercise biology, and post-COVID metabolic health. His multilingual ability and international collaborations make him a bridge between cultures and scientific communities.

🔮 Legacy and Future Contributions

Dr. Ghanemi's trajectory suggests a lasting legacy in translational medicine. His integration of molecular research, clinical relevance, and public health awareness positions him to advance therapeutic development in obesity, regenerative strategies, and age-related diseases. With current projects involving SPARC’s therapeutic applications, vascular biology, and bioprinted tissues, Dr. Ghanemi is at the vanguard of modern biomedical science. His commitment to publishing, mentoring, and interdisciplinary exploration signals continued contributions to global health and scientific progress.

Publications

📄 A Single Intraperitoneal Secreted Protein Acidic and Rich in Cysteine Injection in Mice Is Towards an Exercise-like Phenotype
Authors: Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Journal: Biology
Year: 2025

📄 Obesity and Bone Mineral Density Protection Paradox in Chronic Kidney Disease: Secreted Protein Acidic and Rich in Cysteine as a Piece of the Puzzle?
Authors: Abdelaziz Ghanemi, Fabrice Mac-Way
Journal: Life
Year: 2023

📄 Secreted Protein Acidic and Rich in Cysteine (SPARC) to Manage Coronavirus Disease-2019 (COVID-19) Pandemic and the Post-COVID-19 Health Crisis
Authors: Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Journal: Medicines
Year: 2023

📄 Secreted Protein Acidic and Rich in Cysteine (SPARC)—Mediated Exercise Effects: Illustrative Molecular Pathways against Various Diseases
Authors: Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Journal: Diseases
Year: 2023

📄 DNA Damage as a Mechanistic Link between Air Pollution and Obesity?
Authors: Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Journal: Medicines
Year: 2022