Tiangong University | China
Author Profile
Orcid
🎓 Early Academic Pursuits
Dr. Yunlong Liu was born in August 1995 in Chengde, Hebei Province, China. His academic journey began with a strong foundation in the biological sciences, which led him to pursue a Ph.D. in Biochemistry and Molecular Biology at China Agricultural University from 2018 to 2023. During his doctoral studies, he delved into structural biology, focusing on unraveling the molecular mechanisms of transcriptional regulation mediated by nuclear receptors and other transcription factors. His exceptional research prowess and dedication earned him prestigious accolades, such as the National Ph.D. Scholarship and the Outstanding Doctoral Dissertation Award.
👨🏫 Professional Endeavors
Since August 2023, Dr. Liu has been serving as a Lecturer at the College of Life Sciences, Tiangong University. His transition from a promising Ph.D. scholar to a faculty member highlights his commitment to academia and scientific research. His role involves not only imparting knowledge to the next generation of scientists but also continuing his cutting-edge research in structural biology and transcriptional regulation.
🔬 Contributions and Research Focus
Dr. Liu's research is centered on understanding the structural and functional dynamics of nuclear receptors and transcription factors. He has determined seven crystal structures of protein monomers, protein-protein complexes, and protein-nucleic acid complexes. His work led to the identification of a nuclear receptor inhibitor with 100-fold enhanced efficacy, marking a significant breakthrough in molecular biology. His research contributions are reflected in his publications, including a sole first-author paper in Nucleic Acids Research with an impact factor of 19.16, as well as co-authored papers in Cell Discovery with an impact factor of 38.1 and the Journal of Biological Chemistry with an impact factor of 5.8. He has also played a crucial role in leading prestigious research projects, such as the National Natural Science Foundation of China and the Tianjin Top Scientist Studio Program, securing substantial funding for his research. His studies contribute to a deeper understanding of transcriptional regulation, a crucial aspect in fields like genetics, cancer research, and pharmaceutical development.
🏆 Accolades and Recognition
Dr. Liu’s remarkable contributions to structural biology have been acknowledged with numerous awards. He received the Outstanding Doctoral Dissertation Award and the Outstanding Ph.D. Graduate Award from China Agricultural University in 2023. In 2022, he was awarded the National Ph.D. Scholarship, ranking second in his college. During his undergraduate years, he secured the Second Prize in the National Mathematical Modeling Competition in 2016 and was a recipient of the National Inspirational Scholarships in 2016 and 2017. He was also honored as an Outstanding Graduate in 2018. These accolades highlight his exceptional academic excellence and research contributions.
🌍 Impact and Influence
Dr. Liu’s groundbreaking work has significantly influenced the field of structural biology, particularly in transcriptional regulation. His high-impact publications and research findings pave the way for advancements in drug discovery, genetic regulation, and medical therapeutics. By identifying novel molecular mechanisms and inhibitors, his work has the potential to drive innovations in treating diseases linked to transcriptional dysregulation, such as cancer and metabolic disorders. Beyond research, Dr. Liu's role as a lecturer enables him to inspire and mentor young scientists. His transition from a student to a faculty member positions him as a role model for aspiring biochemists and molecular biologists.
🚀 Legacy and Future Contributions
Looking ahead, Dr. Liu is set to make even more substantial contributions to the scientific community. His ongoing research projects, including those funded by national and provincial grants, will continue to advance the understanding of transcriptional regulation. With his expertise in structural biology and biochemistry, he is poised to make further discoveries that will shape the future of molecular medicine. As he continues his academic journey, Dr. Liu’s legacy will be defined by his unwavering dedication to science, his contributions to groundbreaking research, and his role in nurturing the next generation of scientists. His story is a testament to the power of perseverance, intellect, and scientific curiosity in pushing the boundaries of knowledge.
Publications
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📄The Progress and Evolving Trends in Nucleic-Acid-Based Therapies
Authors: Yunlong Liu, Chunmiao Wang, Xiuping Fu, Mengtian Ren
Journal: Biomolecules
Year: 2025
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📄Structural Basis of Nucleic Acid Recognition and 6mA Demethylation by Caenorhabditis elegans NMAD-1A
Authors: Guohui Shang, Meiting Yang, Min Li, Lulu Ma, Yunlong Liu, Jun Ma, Yiyun Chen, Xue Wang, Shilong Fan, Mengjia Xie, et al.
Journal: International Journal of Molecular Sciences
Year: 2024
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📄Structures of Human TR4LBD–JAZF1 and TR4DBD–DNA Complexes Reveal the Molecular Basis of Transcriptional Regulation
Authors: Yunlong Liu, Lulu Ma, Min Li, Zizi Tian, Meiting Yang, Xi Wu, Xue Wang, Guohui Shang, Mengjia Xie, Yiyun Chen, et al.
Journal: Nucleic Acids Research
Year: 2023
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📄Structures of MPND Reveal the Molecular Recognition of Nucleosomes
Authors: Meiting Yang, Xiaorong Li, Zizi Tian, Lulu Ma, Jun Ma, Yunlong Liu, Guohui Shang, Ailing Liang, Wei Wu, Zhongzhou Chen
Journal: International Journal of Molecular Sciences
Year: 2023
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📄Structural Insights into the Interactions and Epigenetic Functions of Human Nucleic Acid Repair Protein ALKBH6
Authors: Lulu Ma, Hongyun Lu, Zizi Tian, Meiting Yang, Jun Ma, Guohui Shang, Yunlong Liu, Mengjia Xie, Guoguo Wang, Wei Wu, et al.
Journal: Journal of Biological Chemistry
Year: 2022