National Research Centre | Egypt
Author Profile
Scopus
🎓 Early Academic Pursuits
Dr. Mohamed Abdel-Hamid’s academic journey began with a strong foundation in pharmaceutical sciences, graduating with high honors from Misr International University in 2002. His passion for genetic research propelled him toward advanced studies, culminating in a Master’s degree in Molecular Genetics (2010) and a Ph.D. in Molecular Genetics (2016) from Cairo University. His doctoral work, focused on ASPM gene mutations in microcephaly, set the stage for his future in neurogenetic diagnostics and developmental disorders.
🧪 Professional Endeavors
Since 2004, Dr. Abdel-Hamid has served in progressive roles at Egypt’s prestigious National Research Center, advancing from a fellowship student to his current position as Associate Professor in the Department of Medical Molecular Genetics. His work bridges bench science with clinical relevance, and he is especially known for implementing cutting-edge genetic screening technologies in national medical research. He has undergone specialized training in exome sequencing, NGS, and bioinformatics at leading institutes including the University of California, San Diego, Pasteur Institute (France), and through COST fellowships in Germany—skills that have enhanced Egypt’s scientific capacity in rare genetic disease diagnostics.
🔬 Contributions and Research Focus
Dr. Abdel-Hamid’s research focuses on rare neurodevelopmental and metabolic disorders, whole exome sequencing, and gene discovery in congenital syndromes. He has made key contributions to understanding:
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ACTL6B-related developmental brain disorders
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PTPMT1 and FLVCR1-related neurodevelopmental syndromes
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Novel variants in ESAM, ANTXR1, and GON4L affecting neurological and dental phenotypes
His collaborations span global research networks, contributing to Genetics in Medicine, NPJ Genomic Medicine, Brain, and Saudi Dental Journal, among others.
🏅 Accolades and Recognition
Dr. Abdel-Hamid’s excellence has been repeatedly recognized. Highlights include:
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🏆 The State Award for Encouragement in Medical Research (2018)
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🎓 Prof. Dr. Samia Temtamy Prize for young researchers (2011)
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📚 Multiple young researcher publication awards from the National Research Centre (2013, 2015, 2016)
These accolades celebrate both the quality and societal relevance of his scientific contributions.
🌍 Impact and Influence
A respected member of numerous professional organizations including the American Society of Human Genetics and the African Genetic Society, Dr. Abdel-Hamid is a frequent speaker at international conferences. His work has influenced genetic screening protocols in Egypt and contributed to the diagnostic classification of previously unresolved developmental conditions. He also plays a key mentoring role for the next generation of geneticists.
🔮 Legacy and Future Contributions
Dr. Mohamed Abdel-Hamid’s career exemplifies dedication to precision medicine and global collaboration. His ongoing work in brain malformation diagnostics and molecular therapeutics is shaping the future of personalized medicine in the Arab world and beyond. With his robust research pipeline, international visibility, and unwavering commitment to science, Dr. Abdel-Hamid is poised to lead transformative genetic discoveries that will benefit patients, families, and health systems worldwide.
Publications
📄Clinical and Genetic Delineation of Autosomal Recessive and Dominant ACTL6B-Related Developmental Brain Disorders
Authors: Cali E, Quirin T, Rocca C, Abdel-Hamid MS, et al.
Journal: Genetics in Medicine
Year: 2024
📄Biallelic PTPMT1 Variants Disrupt Cardiolipin Metabolism and Lead to a Neurodevelopmental Syndrome
Authors: Falabella M, Pizzamiglio C, Tabara LC, Abdel-Hamid MS, et al.
Journal: Brain
Year: 2024
📄Biallelic Variation in the Choline and Ethanolamine Transporter FLVCR1 Underlies a Severe Developmental Disorder Spectrum
Authors: Calame DG, Wong JH, Panda P, Abdel-Hamid MS, et al.
Journal: Genetics in Medicine
Year: 2024
📄Biallelic Loss-of-Function Variants in GON4L Cause Microcephaly and Brain Structure Abnormalities
Authors: Li S, Takada S, Abdel-Salam GMH, Abdel-Hamid MS, et al.
Journal: NPJ Genomic Medicine
Year: 2024
📄Abnormal Dental Phenotypes in GAPO Syndrome: A Descriptive Study with a New ANTXR1 Variant & Insights on Teeth Eruption
Authors: El-Moataz Bellah Ahmed N, Mostafa MI, Abdel-Hamid MS, Mehrez M
Journal: Saudi Dental Journal
Year: 2024